List of substrates found:


Substrate: INF gamma R (Interferon receptor)
Seq-ID: P15260 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
interferon-gamma receptor activity integral to plasma membrane blood coagulation,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 457 TVIKAPTSFGYDKPHVLVDLL JAK1 8156998
LTP
1.00
 STAT1 SH2 IFNGR1
0.37
 - low

Substrate: SH2-B beta signaling protein (Unclassified)
Seq-ID: ENSP00000352232 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-74717   EGFR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity cytoplasm,
nucleus,
membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 439 ESNDRLSQGAYGGLSDRPSAS JAK1 12551917
LTP
0.10
 - -
0.71
 - medium
Y 494 TGTVHPLSAPYPPLDTPETAT JAK1 12551917
LTP
0.14
 - -
0.76
 - medium

Substrate: STAT 1 (Transcription factor)
Seq-ID: P42224 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74755   ERBB2_HUMAN
MINT-7264037   CBP_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm,
nucleolus		 transcription from RNA polymerase II promoter,
activation of caspase activity,
I-kappaB kinase/NF-kappaB cascade,
interspecies interaction between organisms,
regulation of transcription, DNA-dependent,
response to virus,
tyrosine phosphorylation of STAT protein
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 701 MELDGPKGTGYIKTELISVSE JAK1 11438544
LTP
1.00
 STAT1 SH2;
STAT2 SH2		 -
0.47
 1BF5 139.74%
Y 701 MELDGPKGTGYIKTELISVSE JAK1 14978237
LTP
1.00
 STAT1 SH2;
STAT2 SH2		 -
0.47
 1BF5 139.74%

Substrate: Tyk2 (Cytoplasmic tyrosine kinase)
Seq-ID: P29597 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-73134   INAR1_HUMAN
MINT-4507312   KPCA_HUMAN
MINT-6793782   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Janus kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding		 cytoplasm,
cytoskeleton,
nucleus,
membrane		 peptidyl-tyrosine phosphorylation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1054 LAKAVPEGHEYYRVREDGDSP JAK1 8702790
LTP
1.00
 - TyrKc
0.26
 - medium
Y 1055 AKAVPEGHEYYRVREDGDSPV JAK1 8702790
LTP
1.00
 - TyrKc
0.24
 - medium

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