List of substrates found:


Substrate: c-myc (Myc proto-oncogene protein (c-myc))
Seq-ID: P01108 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity spindle,
nuclear body,
nucleolus,
axon		 B cell apoptosis,
branching involved in ureteric bud morphogenesis,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
skeletal system morphogenesis,
cellular response to protein stimulus,
response to alkaloid,
detection of mechanical stimulus involved in sensory perception of sound,
positive regulation of B cell apoptosis,
release of cytochrome c from mitochondria,
activation of caspase activity,
protein processing,
negative regulation of survival gene product expression,
response to radiation,
negative regulation of protein binding,
induction of apoptosis by intracellular signals,
middle ear morphogenesis,
activation of pro-apoptotic gene products,
positive regulation of transcription from RNA polymerase II promoter,
DNA fragmentation involved in apoptotic nuclear change,
pigmentation,
positive regulation of metanephric cap mesenchymal cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 358 SDTEENDKRRTHNVLERQRRN PAK2 14749374
LTP
1.00
 - HLH
0.87
 - medium
S 373 ERQRRNELKRSFFALRDQIPE PAK2 14749374
LTP
1.00
 - HLH
0.52
 - medium
T 400 APKVVILKKATAYILSIQADE PAK2 14749374
LTP
0.91
 - HLH
0.36
 - medium

Substrate: MAP kinase-interacting serine/threonine-protein kinase 1 (Protein serine/threonine kinase activity)
Seq-ID: O08605 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-17724   MK03_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 protein amino acid phosphorylation,
response to stress,
regulation of translation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 34 SDKRRKKKRKTRATDSLPGKF PAK2 15234964
LTP
0.27
 - -
0.59
 - medium
S 39 KKKRKTRATDSLPGKFEDVYQ PAK2 15234964
LTP
0.89
 - -
0.45
 - medium

Substrate: Merlin (Probably acts as a ,15, stabilizing protein)
Seq-ID: P35240 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytoskeletal protein binding early endosome,
cytoskeleton,
nucleolus,
ruffle membrane,
extrinsic to membrane,
perinuclear region of cytoplasm,
filopodium membrane		 negative regulation of DNA replication,
actin cytoskeleton organization,
negative regulation of tyrosine phosphorylation of Stat5 protein,
positive regulation of stress fiber assembly,
negative regulation of cell proliferation,
regulation of hippo signaling cascade,
negative regulation of cell-matrix adhesion,
Schwann cell proliferation,
negative regulation of cell-cell adhesion,
negative regulation of cell migration,
negative regulation of tyrosine phosphorylation of Stat3 protein
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 518 DFKDTDMKRLSMEIEKEKVEY PAK2 15378014
LTP
1.00
 MOD_PKA_1
 - COIL
0.46
 - medium

Substrate: Myosin regulatory light chain 2, smooth muscle isoform
Seq-ID: P24844 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
structural constituent of muscle,
motor activity		 muscle myosin complex muscle contraction,
regulation of muscle contraction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 TTKKRPQRATSNVFAMFDQSQ PAK2 10047984
LTP
0.91
 - -
0.52
 - low

Substrate: PAK2 (Protein Kinase C-related protein kinase)
Seq-ID: Q29502 [Oryctolagus cuniculus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 cytosol,
nucleoplasm,
perinuclear region of cytoplasm,
membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 19 DKPPAPPVRMSSTIFSTGGKD PAK2 10075701
LTP
0.42
 - -
0.79
 - low
S 20 KPPAPPVRMSSTIFSTGGKDP PAK2 10075701
LTP
1.00
 - -
0.78
 - low
S 55 EEKKPRNKIISIFSGTEKGSK PAK2 10075701
LTP
0.59
 - -
0.62
 - low
S 141 DSNTVKQKYLSFTPPEKDGFP PAK2 10075701
LTP
0.76
 - -
0.56
 - low
S 165 PALNTKVSETSAVVTEEDDDD PAK2 10075701
LTP
0.32
 - -
0.75
 - low
S 192 VIAPRPDHTKSIYTRSVIDPI PAK2 10075701
LTP
0.87
 - -
0.56
 - low
S 197 PDHTKSIYTRSVIDPIPAPVG PAK2 10075701
LTP
0.57
 - -
0.56
 - low
T 402 QITPEQSKRSTMVGTPYWMAP PAK2 10075701
LTP
1.00
 - S_TKc
0.37
 - low

Substrate: PRL (prolactin precusor (Prl) (from PhosphoBase))
Seq-ID: P01236 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hormone activity,
prolactin receptor binding		 extracellular region regulation of multicellular organism growth,
lactation,
female pregnancy,
cell surface receptor linked signaling pathway,
cell proliferation,
positive regulation of JAK-STAT cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 207 YNLLHCLRRDSHKIDNYLKLL PAK2 11943200
LTP
1.00
 - Hormone_1
0.07
 3D48 8.20%

Substrate: PRL (prolactin precusor (Prl) (from PhosphoBase))
Seq-ID: P01237 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hormone activity,
prolactin receptor binding		 extracellular region,
stored secretory granule		 ovulation cycle,
parturition,
response to organic cyclic substance,
response to drug,
response to estradiol stimulus,
cellular response to hormone stimulus,
regulation of ossification,
response to nutrient,
multicellular organismal response to stress,
lactation,
positive regulation of epithelial cell proliferation,
response to lipopolysaccharide,
circadian rhythm,
response to ethanol
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 178 AKGNEIYLVWSQLPSLQGVDE PAK2 11943200
LTP
1.00
 - Hormone_1
0.22
 - low

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