List of substrates found:


Substrate: FYN (Cytoplasmic tyrosine kinase)
Seq-ID: P06241 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14847   WASP_HUMAN
MINT-15132   HNRPK_RAT
MINT-15408   KHDR1_HUMAN
MINT-15425   SHC1_HUMAN
MINT-16566   FYB_HUMAN
MINT-46000   CTNB1_MOUSE
MINT-50377   RASH_HUMAN
MINT-50652   MAP2_HUMAN
MINT-50666   CBL_HUMAN
MINT-61277   G3BP1_HUMAN
MINT-61574   CTNB1_RAT
MINT-2792095   PAK2_HUMAN
MINT-2792412   ADA15_HUMAN
MINT-2859062   ATX1_HUMAN
MINT-3381335   VGFR2_HUMAN
MINT-3381360   SRC_HUMAN
MINT-3381384   NCK1_HUMAN
MINT-4085360   TNR6_HUMAN
MINT-7214580   5HT6R_HUMAN
MINT-7245838   TRI39_HUMAN
MINT-7245886   ORC1_HUMAN
MINT-7245898   AKAP6_HUMAN
MINT-7245910   CENPA_HUMAN
MINT-7245922   LRBA_HUMAN
MINT-7245934   TRAIP_HUMAN
MINT-7245958   RPP38_HUMAN
MINT-7245970   HCN2_HUMAN
MINT-7246030   ASAP2_HUMAN
MINT-7246102   SYNJ2_HUMAN
MINT-7246150   RIMS1_HUMAN
MINT-7246210   DLGP4_HUMAN
MINT-7246222   LAP2B_HUMAN
MINT-7246246   TGON2_HUMAN
MINT-7246270   EPS15_HUMAN
MINT-7246306   CD2AP_HUMAN
MINT-7246318   MLL4_HUMAN
MINT-7246402   ARHGB_HUMAN
MINT-7246426   FLNC_HUMAN
MINT-7246450   SP1_HUMAN
MINT-7246474   RIMS2_HUMAN
MINT-7246522   ABL1_HUMAN
MINT-7246534   SNX12_HUMAN
MINT-7246558   M4K1_HUMAN
MINT-7246570   PRIC3_HUMAN
MINT-7246594   WNK2_HUMAN
MINT-7246630   RTN4_HUMAN
MINT-7246666   SF3B4_HUMAN
MINT-7246678   NFASC_HUMAN
MINT-7246714   GCF_HUMAN
MINT-7246726   PPR3D_HUMAN
MINT-7246750   BAZ2A_HUMAN
MINT-7246774   KI67_HUMAN
MINT-7246798   DDX41_HUMAN
MINT-7246810   DPOD1_HUMAN
MINT-7246834   FLNA_HUMAN
MINT-7246846   CDC27_HUMAN
MINT-7246870   SNX8_HUMAN
MINT-7246882   ABL2_HUMAN
MINT-7246918   ASAP1_HUMAN
MINT-7246930   MED14_HUMAN
MINT-7246954   WIPF1_HUMAN
MINT-7246978   E41L3_HUMAN
MINT-7247002   BCAR1_HUMAN
MINT-7247014   MYPT1_HUMAN
MINT-7247038   CAF1A_HUMAN
MINT-7247050   SHRM2_HUMAN
MINT-7247074   VP13A_HUMAN
MINT-7247086   CDKL5_HUMAN
MINT-7247098   ICAL_HUMAN
MINT-7247122   RRAS_HUMAN
MINT-7247134   NELFB_HUMAN
MINT-7247146   SPN90_HUMAN
MINT-7247158   CKAP5_HUMAN
MINT-7247170   FANCA_HUMAN
MINT-7247182   HDAC6_HUMAN
MINT-7247194   SNX3_HUMAN
MINT-7247206   BRPF3_HUMAN
MINT-7247230   XRCC1_HUMAN
MINT-7247242   DAB2_HUMAN
MINT-7247254   M4K5_HUMAN
MINT-7247290   STF1_HUMAN
MINT-7247302   DOCK1_HUMAN
MINT-7247350   BRCA2_HUMAN
MINT-7247374   RPGF1_HUMAN
MINT-7247422   DAG1_HUMAN
MINT-7247434   SUV92_HUMAN
MINT-7247446   FCG2B_HUMAN
MINT-7247458   FCG2C_HUMAN
MINT-7247482   CELR3_HUMAN
MINT-7247530   SOS1_HUMAN
MINT-7247554   MOS_HUMAN
MINT-7247566   SNX17_HUMAN
MINT-7306611   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
metal ion binding,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 plasma membrane,
endosome,
cytosol		 learning,
feeding behavior,
calcium ion transport,
interspecies interaction between organisms,
T cell receptor signaling pathway,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 28 RDGSLNQSSGYRYGTDPTPQH PDGFR_beta 9425276
LTP
0.06
 - -
0.68
 --

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P05622 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2832864   NHRF1_HUMAN
MINT-2832910   NHRF2_MOUSE
MINT-2832964   NHRF2_HUMAN
MINT-2833145   PTEN_MOUSE
MINT-6765460   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
ATP binding		 integral to plasma membrane skeletal system morphogenesis,
kidney development,
smooth muscle tissue development,
in utero embryonic development,
nitrogen compound metabolic process,
adrenal gland development,
regulation of peptidyl-tyrosine phosphorylation,
tissue homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 856 LARDIMRDSNYISKGSTYLPL PDGFR_beta 2479827
LTP
1.00
 - TyrKc
0.10
 - medium

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 562 LIMLWQKKPRYEIRWKVIESV PDGFR_beta 10821867
LTP
1.00
 - -
0.06
 - medium
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.15
 - medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.16
 - medium
Y 716 DKRRPPSAELYSNALPVGLPL PDGFR_beta 8940081
LTP
1.00
 GRB2 SH2;
GRB7 SH2		 TyrKc
0.46
 - medium
Y 716 DKRRPPSAELYSNALPVGLPL PDGFR_beta 7935391
LTP
1.00
 GRB2 SH2;
GRB7 SH2		 TyrKc
0.46
 - medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.45
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta N.N.
LTP
0.28
 PTPN11 SH2 TyrKc
0.21
 - medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta 10391677
LTP
0.28
 PTPN11 SH2 TyrKc
0.21
 - medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.25
 - medium
Y 775 DIESSNYMAPYDNYVPSAPER PDGFR_beta 8940081
LTP
1.00
 GRB2 SH2;
GRB7 SH2;
STAT5 SH2		 TyrKc
0.34
 - medium
Y 778 SSNYMAPYDNYVPSAPERTCR PDGFR_beta 10821867
LTP
0.02
 - TyrKc
0.33
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 10821867
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 2550144
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
 NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2		 -
0.61
 - medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
 PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2		 -
0.75
 - medium

Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P26450 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19635   CTNB1_MOUSE
MINT-19729   PK3CB_HUMAN
MINT-19828   SH3G1_MOUSE
MINT-59445   EPOR_MOUSE
MINT-6381887   IRS1_MOUSE
MINT-7214388   LYN_MOUSE
MINT-7214429   BLK_MOUSE
MINT-7214442   FYN_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ErbB-3 class receptor binding,
1-phosphatidylinositol-3-kinase activity,
insulin-like growth factor receptor binding,
phosphoinositide 3-kinase regulator activity,
insulin receptor binding,
insulin receptor substrate binding		 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex B cell differentiation,
protein amino acid phosphorylation,
negative regulation of apoptosis,
positive regulation of cell migration,
signal transduction,
insulin-like growth factor receptor signaling pathway,
negative regulation of cell-matrix adhesion,
negative regulation of osteoclast differentiation,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 508 CQTQERYSKEYIGKFKREGNE PDGFR_beta 8086421
LTP
1.00
 - -
0.48
 2RD0 86.90%

Substrate: Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID: Q06124 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50695   CATA_HUMAN
MINT-61523   ERBB4_HUMAN
MINT-61552   GRB2_HUMAN
MINT-74689   EGFR_HUMAN
MINT-74691   ERBB2_HUMAN
MINT-74885   DDR1_HUMAN
MINT-6169406   GAB1_HUMAN
MINT-6169440   PAXI_HUMAN
MINT-6762811   IRS1_RAT
MINT-6793881   CAV1_HUMAN
MINT-6798640   MET_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine phosphatase activity cytosol
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 546 EQKSKRKGHEYTNIKYSLADQ PDGFR_beta 8041791
LTP
1.00
 GRB2 SH2 -
0.51
 --

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