Substrate: Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID: P35235 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7258938   FAK1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
peptide hormone receptor binding		 reproductive process in a multicellular organism,
regulation of protein export from nucleus,
glucose homeostasis,
regulation of multicellular organism growth,
nerve growth factor receptor signaling pathway,
negative regulation of cortisol secretion,
positive regulation of signal transduction,
DNA damage checkpoint,
positive regulation of hormone secretion,
negative regulation of growth hormone secretion,
activation of MAPK activity,
axonogenesis,
negative regulation of insulin secretion,
triglyceride metabolic process,
organ growth,
hormone metabolic process,
hormone-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 62 THIKIQNTGDYYDLYGGEKFA - 15592455
HTP
0.97
 - SH2
0.25
 2SHP 9.61%
Y 304 DGDPNEPVSDYINANIIMPEF - 8995399
LTP
1.00
 - PTPc
0.45
 3B7O 0.44%
Y 327 KCNNSKPKKSYIATQGCLQNT - 8995399
LTP
1.00
 - PTPc
0.42
 3B7O 2.62%
Y 546 EQKSKRKGHEYTNIKYSLVDQ - 12923167
LTP
1.00
 - -
0.47
 --
Y 584 AEMREDSARVYENVGLMQQQR - 12522270
HTP
0.82
 - -
0.51
 --

Substrate: Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID: Q06124 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50695   CATA_HUMAN
MINT-61523   ERBB4_HUMAN
MINT-61552   GRB2_HUMAN
MINT-74689   EGFR_HUMAN
MINT-74691   ERBB2_HUMAN
MINT-74885   DDR1_HUMAN
MINT-6169406   GAB1_HUMAN
MINT-6169440   PAXI_HUMAN
MINT-6762811   IRS1_RAT
MINT-6793881   CAV1_HUMAN
MINT-6798640   MET_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine phosphatase activity cytosol
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 62 THIKIQNTGDYYDLYGGEKFA - 15592455
HTP
0.97
 - SH2
0.25
 2SHP 9.61%
Y 62 THIKIQNTGDYYDLYGGEKFA - 18083107
HTP
0.97
 - SH2
0.25
 2SHP 9.61%
Y 63 HIKIQNTGDYYDLYGGEKFAT - 18083107
HTP
0.97
 - SH2
0.24
 2SHP 6.55%
Y 304 DGDPNEPVSDYINANIIMPEF - 12531430
LTP
1.00
 GRB2 SH2 PTPc
0.45
 3B7O 0.44%
Y 546 EQKSKRKGHEYTNIKYSLADQ - 11684012
LTP
1.00
 GRB2 SH2 -
0.51
 --
Y 546 EQKSKRKGHEYTNIKYSLADQ PDGFR_beta 8041791
LTP
1.00
 GRB2 SH2 -
0.51
 --
Y 546 EQKSKRKGHEYTNIKYSLADQ - 12531430
LTP
1.00
 GRB2 SH2 -
0.51
 --
Y 546 EQKSKRKGHEYTNIKYSLADQ - 12721296
LTP
1.00
 GRB2 SH2 -
0.51
 --
Y 584 AEMREDSARVYENVGLMQQQK - 11684012
LTP
0.82
 GRB7 SH2 -
0.51
 --
Y 584 AEMREDSARVYENVGLMQQQK - 8622870
LTP
0.82
 GRB7 SH2 -
0.51
 --
Y 584 AEMREDSARVYENVGLMQQQK - 16094384
HTP
0.82
 GRB7 SH2 -
0.51
 --
Y 584 AEMREDSARVYENVGLMQQQK - 18083107
HTP
0.82
 GRB7 SH2 -
0.51
 --
Y 584 AEMREDSARVYENVGLMQQQK - 17287340
HTP
0.82
 GRB7 SH2 -
0.51
 --
S 595 ENVGLMQQQKSFR         - 17287340
HTP
0.50
 - -
0.38
 --

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