Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

BIRC4
Erzin
Estrogen receptor alpha
MAP3K5

Substrate:

BIRC4 (caspase inhibitor activity, protein binding)

Seq-ID:

P98170 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13839   CASP3_HUMAN
MINT-14016   MAGD1_HUMAN
MINT-25026   CASP9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
caspase inhibitor activity, zinc ion binding, ligase activity, protein binding	cytosol	apoptosis, anti-apoptosis, response to DNA damage stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	87	DSAVGRHRKVSPNCRFINGFY	PKB_beta	14645242	LTP	1.00		-	BIR	0.23	2POI	16.39%

Substrate:

Erzin (Connection of cytoscheletro structure to plasma membrane)

Seq-ID:

P15311 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cell adhesion molecule binding, actin filament binding	filopodium, cortical cytoskeleton, actin filament, cytosol, ruffle membrane, microvillus membrane, extrinsic to membrane, apical plasma membrane	membrane to membrane docking, regulation of cell shape, actin filament bundle assembly, cytoskeletal anchoring at plasma membrane, leukocyte cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	567	NMRQGRDKYKTLRQIRQGNTK	PKB_beta	15531580	LTP	0.95		-	ERM	0.76	-	-

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	167	RRQGGRERLASTNDKGSMAME	PKB_beta	11139588	LTP	0.28	MOD_PKB_1	-	Oest_recep	0.75	-	-

Substrate:

MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)

Seq-ID:

Q99683 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16168   M3K3_HUMAN
MINT-18083   M3K2_HUMAN
MINT-18459   DAB2P_HUMAN
MINT-3391607   MP2K7_HUMAN
MINT-7263196   ARRB2_HUMAN
MINT-7263254   ARRB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein homodimerization activity, ATP binding, caspase activator activity, MAP kinase kinase kinase activity		induction of apoptosis by extracellular signals, apoptosis, activation of JUN kinase activity, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	83	SSSATRGRGSSVGGGSRRTTV	PKB_beta	11154276	LTP	0.18	MOD_PKB_1	-	-	0.61	-	-