a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	MAP2K4 (Serine/threonine kinase)
Seq-ID:	P45985 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-7263269   ARRB1_HUMAN MINT-7263286   ARRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine kinase activity, ATP binding, protein tyrosine kinase activity, protein binding protein amino acid phosphorylation, JNK cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	261	SGQLVDSIAKTRDAGCRPYMA	MAP3K5	15911620	LTP	1.00		-	S_TKc	0.24	-	medium

Substrate:	MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)
Seq-ID:	O35099 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process magnesium ion binding, protein homodimerization activity, ATP binding, caspase activator activity, MAP kinase kinase kinase activity apoptosis, activation of MAPK activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	845	RLAGINPCTETFTGTLQYMAP	MAP3K5	11920685	LTP	1.00		-	S_TKc	0.24	-	low

Substrate:	MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)
Seq-ID:	Q99683 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16168   M3K3_HUMAN MINT-18083   M3K2_HUMAN MINT-18459   DAB2P_HUMAN MINT-3391607   MP2K7_HUMAN MINT-7263196   ARRB2_HUMAN MINT-7263254   ARRB1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process magnesium ion binding, protein homodimerization activity, ATP binding, caspase activator activity, MAP kinase kinase kinase activity induction of apoptosis by extracellular signals, apoptosis, activation of JUN kinase activity, interspecies interaction between organisms
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	966	AGSNEYLRSISLPVPVLVEDT	MAP3K5	10411906	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.33	-	-

Substrate:	p21 (Cyclin-dependent kinase inhibitor 1 (p21))
Seq-ID:	P38936 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50392   CC45L_HUMAN MINT-50407   CDC6_HUMAN MINT-50418   CDK4_HUMAN MINT-50421   CDK6_HUMAN MINT-50432   CCNB2_HUMAN MINT-50437   CCND1_HUMAN MINT-50441   CCND3_HUMAN MINT-50445   GEMI_HUMAN MINT-50660   CCNB1_HUMAN MINT-73322   VE7_HPV16 MINT-73323   CDK2_HUMAN MINT-1774121   SKP2_HUMAN MINT-1780042   MCM7_HUMAN MINT-1891378   P53_HUMAN MINT-2635177   CCNE1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cyclin-dependent protein kinase inhibitor activity, metal ion binding cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	98	ELGGGRRPGTSPALLQGTAEE	MAP3K5	17325029	LTP	0.13		-	-	0.78	-	medium