List of substrates found:


Substrate: 14-3-3 beta/alpha (14-3-3 protein beta/alpha (protein kinase C inhibitor protein-1) (from PhosphoBase))
Seq-ID: P31946 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13707   KSR1_MOUSE
MINT-13962   RIN1_HUMAN
MINT-15934   TPD53_HUMAN
MINT-17162   TSC2_HUMAN
MINT-19367   KS6A1_HUMAN
MINT-24750   BID_HUMAN
MINT-25122   MPIP2_HUMAN
MINT-48491   M3K3_HUMAN
MINT-50344   BRAF_HUMAN
MINT-50346   HSP71_HUMAN
MINT-50347   PI4KB_HUMAN
MINT-50348   U520_HUMAN
MINT-50938   LBR_HUMAN
MINT-50939   SRPK1_HUMAN
MINT-50940   PRKDC_HUMAN
MINT-50943   AFAD_HUMAN
MINT-50945   LARP1_HUMAN
MINT-50946   FRYL_HUMAN
MINT-50947   CSK21_HUMAN
MINT-50948   TSC1_HUMAN
MINT-50949   P85B_HUMAN
MINT-50950   KINH_HUMAN
MINT-50951   UBP8_HUMAN
MINT-50952   SF13A_HUMAN
MINT-50953   ZO2_HUMAN
MINT-50954   STK38_HUMAN
MINT-50956   ACINU_HUMAN
MINT-50957   RABX5_HUMAN
MINT-50958   MYCB2_HUMAN
MINT-50959   C1QBP_HUMAN
MINT-50960   HS90B_HUMAN
MINT-50961   S4A7_HUMAN
MINT-50962   EDC3_HUMAN
MINT-50963   E41L3_HUMAN
MINT-50964   RMD3_HUMAN
MINT-50967   MEP50_HUMAN
MINT-50969   GRP78_HUMAN
MINT-50970   RIOK1_HUMAN
MINT-50971   SON_HUMAN
MINT-50972   TBB5_HUMAN
MINT-50973   PARD3_HUMAN
MINT-50974   SRRM2_HUMAN
MINT-50975   KIF23_HUMAN
MINT-50976   GAPD1_HUMAN
MINT-50977   ALS2_HUMAN
MINT-50978   RGAP1_HUMAN
MINT-50979   M3K2_HUMAN
MINT-50980   OSBL3_HUMAN
MINT-50981   MILK1_HUMAN
MINT-50982   MPRIP_HUMAN
MINT-50983   FRMD6_HUMAN
MINT-50984   MARK3_HUMAN
MINT-50985   PI3R4_HUMAN
MINT-50986   ST38L_HUMAN
MINT-50987   DOCK4_HUMAN
MINT-50988   WEE1_HUMAN
MINT-50991   KLC1_HUMAN
MINT-50992   LSR_HUMAN
MINT-50995   RAI14_HUMAN
MINT-50997   MYCPP_HUMAN
MINT-50998   Q8IXP7_HUMAN
MINT-50999   IRS2_HUMAN
MINT-51527   MARK2_HUMAN
MINT-7233039   IRK2_MOUSE
MINT-7300434   GAB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoserine binding,
protein domain specific binding,
histone deacetylase binding		 cytosol,
melanosome,
perinuclear region of cytoplasm		 cytoplasmic sequestering of protein,
negative regulation of protein amino acid dephosphorylation,
positive regulation of catalytic activity,
Ras protein signal transduction,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 60 YKNVVGARRSSWRVISSIEQK PKC_delta 9705322
LTP
0.77
 - 14_3_3
0.33
 2BQ0 45.90%

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hepatocyte growth factor receptor activity,
ATP binding,
protein binding		 integral to plasma membrane,
basal plasma membrane		 protein amino acid phosphorylation,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 985 VHTPHLDRLVSARSVSPTTEM PKC_delta 15075332
LTP
0.26
 - -
0.44
 --

Substrate: CD227 (CD antigen)
Seq-ID: P15941 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-2880967   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
extracellular region,
cytoplasm,
integral to plasma membrane,
nucleus,
apical plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 1224 THGRYVPPSSTDRSPYEKVSA PKC_delta 11877440
LTP
0.00
 - -
0.52
 - low

Substrate: Cytokeratin 8 (keratin, type II cytoskeletal 8 (cytokeratin 8) (K8) (CK8) (from PhosphoBase))
Seq-ID: P05787 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51056   RAF1_HUMAN
MINT-61555   GRB2_HUMAN
MINT-2984733   ZO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural molecule activity,
protein binding		 cytoplasm,
keratin filament		 cytoskeleton organization,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 74 TAVTVNQSLLSPLVLEVDPNI PKC_delta 15972820
LTP
0.18
 MOD_ProDKin_1
 - -
0.28
 - low

Substrate: E1A-associated protein p300 (Transcription regulatory protein)
Seq-ID: Q09472 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13681   P73_HUMAN
MINT-17787   GATA4_MOUSE
MINT-50178   TF65_HUMAN
MINT-69559   VE7_HPV16
MINT-2584615   TF2B_HUMAN
MINT-2831131   ABL1_HUMAN
MINT-2982535   HIPK2_HUMAN
MINT-2982660   RUNX1_HUMAN
MINT-2983397   CDK2_HUMAN
MINT-4790867   ITF2_HUMAN
MINT-4791678   HIF1A_HUMAN
MINT-4979756   CREB1_MOUSE
MINT-5209851   CREB1_HUMAN
MINT-6628502   LT_SV40
MINT-6665134   E1A_ADE05
MINT-6743403   STRAP_HUMAN
MINT-7263630   P53_HUMAN
MINT-7943702   SENP3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone acetyltransferase activity,
beta-catenin binding,
transcription coactivator activity,
zinc ion binding		 cytoplasm transcription,
response to hypoxia,
histone H4 acetylation,
apoptosis,
positive regulation of transcription factor activity,
cell cycle,
N-terminal peptidyl-lysine acetylation,
interspecies interaction between organisms,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 89 KQLSELLRSGSSPNLNMGVGG PKC_delta 12379484
LTP
0.79
 - -
0.74
 - medium
S 89 KQLSELLRSGSSPNLNMGVGG PKC_delta 12590608
LTP
0.79
 - -
0.74
 - medium

Substrate: HIR (Inward rectifier channel)
Seq-ID: P48050 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
inward rectifier potassium channel activity voltage-gated potassium channel complex
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 53 MADIFTTCVDTRWRYMLMIFS PKC_delta 10206975
LTP
0.12
 - IRK
0.01
 - medium

Substrate: hnRNPK (Ribonucleoprotein)
Seq-ID: P61978 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2859758   PCBP1_HUMAN
MINT-3296872   1433Z_HUMAN
MINT-6803834   ANM1_HUMAN
MINT-6803896   ANM3_HUMAN
MINT-7035260   SRC_HUMAN
MINT-7974306   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
RNA binding,
protein binding		 spliceosomal complex,
cytoplasm,
nucleoplasm,
heterogeneous nuclear ribonucleoprotein complex		 mRNA processing,
signal transduction,
interspecies interaction between organisms,
RNA splicing
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 284 PPSRRDYDDMSPRRGPPPPPP PKC_delta 10329716
LTP
0.74
 MOD_ProDKin_1
 - -
0.95
 --
S 302 PPPGRGGRGGSRARNLPLPPP PKC_delta 10329716
LTP
0.81
 - -
0.94
 --

Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ciliary neurotrophic factor receptor activity,
protein homodimerization activity,
interleukin-27 receptor activity,
ciliary neurotrophic factor receptor binding		 extracellular region,
oncostatin-M receptor complex,
interleukin-6 receptor complex,
extracellular space,
ciliary neurotrophic factor receptor complex		 positive regulation vascular endothelial growth factor production,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of anti-apoptosis,
leukemia inhibitory factor signaling pathway,
response to cytokine stimulus,
negative regulation of interleukin-6-mediated signaling pathway,
positive regulation of tyrosine phosphorylation of Stat1 protein,
positive regulation of adaptive immune response,
ciliary neurotrophic factor-mediated signaling pathway,
positive regulation of T cell proliferation,
positive regulation of osteoblast differentiation,
interleukin-27-mediated signaling pathway,
positive regulation of acute inflammatory response,
positive regulation of cardiac muscle hypertrophy
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 890 GTEGQVERFETVGMEAATDEG PKC_delta 12361954
LTP
0.58
 - -
0.74
 - medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 307 VGLTRRSRTESITATSPASMV PKC_delta 14583092
LTP
1.00
 - -
0.78
 --
S 574 SGGRLPGHRHSAFVPTRSYPE PKC_delta 15516986
LTP
1.00
 - -
0.80
 --

Substrate: Integrin beta 2 (Adhesion molecule)
Seq-ID: P05107 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16748   CSN3_HUMAN
MINT-45894   SHC1_MOUSE
MINT-45897   EPS8_HUMAN
MINT-45904   RBGP1_HUMAN
MINT-45912   GULP1_HUMAN
MINT-45917   NUMB_MOUSE
MINT-45924   DAB1_MOUSE
MINT-45938   IRS1_RAT
MINT-45944   DOK1_MOUSE
MINT-45953   TLN1_MOUSE
MINT-45956   JIP1_HUMAN
MINT-50069   RANB9_HUMAN
MINT-4652127   RADI_HUMAN
MINT-4652150   CYH1_HUMAN
MINT-7226098   ABL1_HUMAN
MINT-7226365   TLN2_HUMAN
MINT-7226634   VAV_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein kinase binding,
glycoprotein binding		 integrin complex apoptosis,
integrin-mediated signaling pathway,
regulation of cell shape,
inflammatory response,
cell-cell signaling,
neutrophil chemotaxis,
cell-matrix adhesion,
regulation of peptidyl-tyrosine phosphorylation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 745 YRRFEKEKLKSQWNNDNPLFK PKC_delta 11700305
LTP
0.13
 - Integrin_b_cyt
0.32
 --
T 758 NNDNPLFKSATTTVMNPKFAE PKC_delta 11700305
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%

Substrate: LIM domain kinase 2 (Serine/threonine kinase)
Seq-ID: P53671 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61744   HIPK3_HUMAN
MINT-3380769   PARD3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
zinc ion binding,
protein binding		 mitochondrion,
nucleus		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 283 ENLEGTLRRRSLRRSNSISKS PKC_delta 15923181
LTP
1.00
 - -
0.64
 - low

Substrate: PEBP1 (phosphatidylethanolamine binding)
Seq-ID: P30086 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-63641   STC2_HUMAN
MINT-3389607   RAF1_HUMAN
MINT-7252186   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
serine-type endopeptidase inhibitor activity,
phosphatidylethanolamine binding,
ATP binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 153 GDHRGKFKVASFRKKYELRAP PKC_delta 14654844
LTP
0.23
 - PBP
0.29
 1BD9 62.30%

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: P28867 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C activity,
metal ion binding,
insulin receptor substrate binding,
ATP binding		 cytoplasm,
membrane		 protein amino acid phosphorylation,
negative regulation of insulin receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
interleukin-10 production,
B cell proliferation,
immunoglobulin mediated immune response,
interleukin-12 production
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 643 PEFLNEKPQLSFSDKNLIDSM PKC_delta 9305920
LTP
1.00
 - S_TK_X
0.36
 - low

Substrate: PKC mu (Serine/threonine kinase)
Seq-ID: Q15139 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C activity,
metal ion binding,
ATP binding,
protein binding		 cytosol,
integral to plasma membrane		 protein amino acid phosphorylation,
signal transduction,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 738 FGFARIIGEKSFRRSVVGTPA PKC_delta 15024053
LTP
1.00
 - S_TKc
0.08
 - medium
S 742 RIIGEKSFRRSVVGTPAYLAP PKC_delta 15024053
LTP
1.00
 - S_TKc
0.12
 - medium

Substrate: Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)
Seq-ID: Q9UBS0 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 nucleoplasm positive regulation of translational initiation,
translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 473 PIRPPSGTKKSKRGRGRPGR  PKC_delta 12529391
LTP
0.11
 - -
0.94
 - medium

Substrate: STAT 3 (Transcription factor)
Seq-ID: P40763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74756   ERBB2_HUMAN
MINT-6764613   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
calcium ion binding,
hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity,
protein kinase binding,
transcription activator activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity		 plasma membrane,
cytoplasm,
nucleus		 interleukin-6-mediated signaling pathway,
eating behavior,
glucose homeostasis,
cellular component movement,
response to estradiol stimulus,
temperature homeostasis,
interspecies interaction between organisms,
JAK-STAT cascade involved in growth hormone signaling pathway,
sexual reproduction,
eye photoreceptor cell differentiation,
negative regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 727 TCSNTIDLPMSPRTLDSLMQF PKC_delta 16951338
LTP
0.75
 - -
0.45
 --

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