Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

c-met
CAE3/BAE3
Connexin 43
CPI-17
Cytokeratin 18
GABA(A) receptor G2
Mybpc3
PKC epsilon
Ras GTPase-activating-like protein IQGAP
Ribosomal protein S6 kinase 2
Troponin I, cardiac muscle

Substrate:

c-met (Receptor tyrosine kinase for hepatocyte growth factor.)

Seq-ID:

P08581 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
hepatocyte growth factor receptor activity, ATP binding, protein binding	integral to plasma membrane, basal plasma membrane	protein amino acid phosphorylation, multicellular organismal development, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	985	VHTPHLDRLVSARSVSPTTEM	PKC_epsilon	15075332	LTP	0.26		-	-	0.44	-	-

Substrate:

CAE3/BAE3 (Ion channel, other)

Seq-ID:

P48751 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inorganic anion exchanger activity	membrane fraction, integral to plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	67	WDPEKPSRSYSERDFEFHRHT	PKC_epsilon	11739292	LTP	0.07		-	-	0.80	-	medium

Substrate:

Connexin 43 (Intercellular channel)

Seq-ID:

P17302 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3088474 ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ion transmembrane transporter activity, signal transducer activity	connexon complex, Golgi-associated vesicle membrane, integral to plasma membrane, membrane raft	muscle contraction, positive regulation of I-kappaB kinase/NF-kappaB cascade, gap junction assembly, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	368	IVDQRPSSRASSRASSRPRPD	PKC_epsilon	15534005	LTP	0.96		-	-	0.88	-	low

Substrate:

CPI-17 (Inhibitor of PPP1CA)

Seq-ID:

Q96A00 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-16604 KC1A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity, protein binding	cytoplasm	regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	38	GGLQKRHARVTVKYDRRELQR	PKC_epsilon	15003508	LTP	1.00	MOD_PKA_2	-	PP1_inhibitor	0.51	-	medium

Substrate:

Cytokeratin 18 (Structural protein)

Seq-ID:

P05783 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51052   1433Z_HUMAN
MINT-51055   RAF1_HUMAN
MINT-61557   GRB2_HUMAN
MINT-67331   EXOC8_HUMAN
MINT-68023   HGS_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	centriolar satellite, keratin filament, perinuclear region of cytoplasm	negative regulation of apoptosis, anatomical structure morphogenesis, cell cycle, interspecies interaction between organisms, Golgi to plasma membrane CFTR protein transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	53	GSRISVSRSTSFRGGMGSGGL	PKC_epsilon	7523419	LTP	0.31		-	-	0.47	-	low
S	53	GSRISVSRSTSFRGGMGSGGL	PKC_epsilon	1374067	LTP	0.31		-	-	0.47	-	low

Substrate:

GABA(A) receptor G2 (Gamma-aminobutyric-acid receptor gamma-2 subunit precursor (from PhosphoBase))

Seq-ID:

P18507 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GABA-A receptor activity, benzodiazepine receptor activity, chloride channel activity, extracellular ligand-gated ion channel activity, protein binding	cell junction, integral to plasma membrane, chloride channel complex, postsynaptic membrane	gamma-aminobutyric acid signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	366	LHYFVSNRKPSKDKDKKKKNP	PKC_epsilon	17875639	LTP	0.11		-	Neur_chan_memb	0.38	-	medium

Substrate:

Mybpc3 (Myosin-binding protein)

Seq-ID:

O70468 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of cytoskeleton, myosin heavy chain binding, actin binding	A band	myosin filament assembly, heart morphogenesis, cardiac muscle contraction, regulation of heart rate, cell adhesion, sarcomere organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	302	DFSSLLKKRDSFRRDSKLEAP	PKC_epsilon	17503784	LTP	0.20	MOD_PKA_1	-	-	0.44	-	low

Substrate:

PKC epsilon (Serine/threonine kinase)

Seq-ID:

Q02156 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2833238   BRAF_HUMAN
MINT-2833275   KPCA_HUMAN
MINT-2833498   KS6A2_HUMAN
MINT-7262288   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, metal ion binding, ATP binding, enzyme binding, signal transducer activity	plasma membrane, endoplasmic reticulum	protein amino acid phosphorylation, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	729	QINQEEFKGFSYFGEDLMP	PKC_epsilon	11964154	LTP	1.00		-	S_TK_X	0.24	-	medium

Substrate:

Ras GTPase-activating-like protein IQGAP (Cytoskeletal protein)

Seq-ID:

P46940 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18637   CDC42_HUMAN
MINT-48071   IKKB_HUMAN
MINT-48397   M3K3_HUMAN
MINT-48707   NFKB2_HUMAN
MINT-61541   GRB2_HUMAN
MINT-3308248   1433Z_HUMAN
MINT-6169583   TS101_HUMAN
MINT-7714840   SHC1_HUMAN
MINT-7714902   SHC1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Ras GTPase activator activity, protein phosphatase binding, calmodulin binding, GTPase inhibitor activity	plasma membrane, actin filament, cytoplasm, nucleus	regulation of small GTPase mediated signal transduction, small GTPase mediated signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1443	KTPDKMKKSKSVKEDSNLTLQ	PKC_epsilon	15355962	LTP	0.96		-	-	0.67	-	medium

Substrate:

Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)

Seq-ID:

Q9UBS0 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	nucleoplasm	positive regulation of translational initiation, translation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	473	PIRPPSGTKKSKRGRGRPGR	PKC_epsilon	12529391	LTP	0.11		-	-	0.94	-	medium

Substrate:

Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))

Seq-ID:

P19429 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent protein binding, troponin T binding, protein kinase binding, protein domain specific binding, troponin C binding, calcium channel inhibitor activity, actin binding	troponin complex	regulation of systemic arterial blood pressure by ischemic conditions, negative regulation of ATPase activity, cellular calcium ion homeostasis, cardiac muscle contraction, vasculogenesis, ventricular cardiac muscle tissue morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	44	HAKKKSKISASRKLQLKTLLL	PKC_epsilon	12551921	LTP	1.00		-	COIL	0.40	1J1D	85.25%