Click on substrate name for additional information.


Substrate: PDK1 (3-phosphoinositide dependent protein kinase-1; serine/threonine kinase)
Seq-ID: O15530 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 9   MARTTSQLYDAVPIQSSVV RET 12738763
LTP
0.68
- -
0.44
--

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 687 RRPAQAFPVSYSSSGARRPSL RET 11470823
LTP
0.12
- -
0.36
--
Y 687 RRPAQAFPVSYSSSGARRPSL RET 8621380
LTP
0.12
- -
0.36
--
Y 806 QDGPLLLIVEYAKYGSLRGFL RET 14711813
LTP
1.00
- TyrKc
0.07
2IVS 24.45%
Y 809 PLLLIVEYAKYGSLRGFLRES RET 14711813
LTP
1.00
- TyrKc
0.06
2IVS 28.38%
Y 826 LRESRKVGPGYLGSGGSRNSS RET 8621380
LTP
1.00
- TyrKc
0.46
2IVS 29.26%
Y 900 ISDFGLSRDVYEEDSYVKRSQ RET 14711813
LTP
1.00
- TyrKc
0.25
2IVS 24.89%
Y 905 LSRDVYEEDSYVKRSQGRIPV RET 14711813
LTP
1.00
- TyrKc
0.27
2IVS 27.07%
Y 981 ERPDNCSEEMYRLMLQCWKQE RET 14711813
LTP
1.00
SH2B1 SH2 TyrKc
0.34
2IVS 19.65%
Y 981 ERPDNCSEEMYRLMLQCWKQE RET 14766744
LTP
1.00
SH2B1 SH2 TyrKc
0.34
2IVS 19.65%
Y 1015 LEKMMVKRRDYLDLAASTPSD RET 14981541
LTP
1.00
PLCG1 SH2;
SHC1 SH2;
Src SH2
-
0.33
--
Y 1029 AASTPSDSLIYDDGLSEEETP RET 8621380
LTP
1.00
Src SH2 -
0.51
--
Y 1029 AASTPSDSLIYDDGLSEEETP RET 14766744
LTP
1.00
Src SH2 -
0.51
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1090 ADGTNTGFPRYPNDSVYANWM RET 14711813
LTP
0.16
GRB2 SH2 -
0.41
--
Y 1096 GFPRYPNDSVYANWMLSPSAA RET 8621380
LTP
1.00
GRB2 SH2 -
0.33
--
Y 1096 GFPRYPNDSVYANWMLSPSAA RET 14711813
LTP
1.00
GRB2 SH2 -
0.33
--


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