a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	PDK1 (3-phosphoinositide dependent protein kinase-1; serine/threonine kinase)
Seq-ID:	O15530 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13835   AKT1_HUMAN MINT-14377   KS6B1_HUMAN MINT-15996   1433F_HUMAN MINT-16333   1433T_HUMAN MINT-17466   FRAP_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process 3-phosphoinositide-dependent protein kinase activity, ATP binding, protein binding plasma membrane, cytosol intracellular signaling pathway, actin cytoskeleton organization, cellular response to insulin stimulus, positive regulation of establishment of protein localization in plasma membrane, negative regulation of protein kinase activity, peptidyl-threonine phosphorylation, activation of protein kinase B activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	9	MARTTSQLYDAVPIQSSVV	RET	12738763	LTP	0.68		-	-	0.44	-	-

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	687	RRPAQAFPVSYSSSGARRPSL	RET	11470823	LTP	0.12		-	-	0.36	-	-
Y	687	RRPAQAFPVSYSSSGARRPSL	RET	8621380	LTP	0.12		-	-	0.36	-	-
Y	806	QDGPLLLIVEYAKYGSLRGFL	RET	14711813	LTP	1.00		-	TyrKc	0.07	2IVS	24.45%
Y	809	PLLLIVEYAKYGSLRGFLRES	RET	14711813	LTP	1.00		-	TyrKc	0.06	2IVS	28.38%
Y	826	LRESRKVGPGYLGSGGSRNSS	RET	8621380	LTP	1.00		-	TyrKc	0.46	2IVS	29.26%
Y	900	ISDFGLSRDVYEEDSYVKRSQ	RET	14711813	LTP	1.00		-	TyrKc	0.25	2IVS	24.89%
Y	905	LSRDVYEEDSYVKRSQGRIPV	RET	14711813	LTP	1.00		-	TyrKc	0.27	2IVS	27.07%
Y	981	ERPDNCSEEMYRLMLQCWKQE	RET	14711813	LTP	1.00		SH2B1 SH2	TyrKc	0.34	2IVS	19.65%
Y	981	ERPDNCSEEMYRLMLQCWKQE	RET	14766744	LTP	1.00		SH2B1 SH2	TyrKc	0.34	2IVS	19.65%
Y	1015	LEKMMVKRRDYLDLAASTPSD	RET	14981541	LTP	1.00		PLCG1 SH2; SHC1 SH2; Src SH2	-	0.33	-	-
Y	1029	AASTPSDSLIYDDGLSEEETP	RET	8621380	LTP	1.00		Src SH2	-	0.51	-	-
Y	1029	AASTPSDSLIYDDGLSEEETP	RET	14766744	LTP	1.00		Src SH2	-	0.51	-	-
Y	1062	LPSTWIENKLYGMSDPNWPGE	RET	14711813	LTP	0.19		FRS2 PTB; IRS1 PTB; PIK3R1 SH2; SHC1 PTB; SHC1 SH2; SHC3 PTB; SHC3 SH2	-	0.43	-	-
Y	1062	LPSTWIENKLYGMSDPNWPGE	RET	14981541	LTP	0.19		FRS2 PTB; IRS1 PTB; PIK3R1 SH2; SHC1 PTB; SHC1 SH2; SHC3 PTB; SHC3 SH2	-	0.43	-	-
Y	1090	ADGTNTGFPRYPNDSVYANWM	RET	14711813	LTP	0.16		GRB2 SH2	-	0.41	-	-
Y	1096	GFPRYPNDSVYANWMLSPSAA	RET	8621380	LTP	1.00		GRB2 SH2	-	0.33	-	-
Y	1096	GFPRYPNDSVYANWMLSPSAA	RET	14711813	LTP	1.00		GRB2 SH2	-	0.33	-	-