List of substrates found:


Substrate: 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (Unclassified)
Seq-ID: ENSGALP00000016789 [Gallus gallus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 695 SRQARQSRRSTQGVTLTDLQE ROCK1 16297917
LTP
1.00
 - -
0.80
 - medium

Substrate: Alpha adducin (Structural protein)
Seq-ID: P35611 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-72730   RFX1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
spectrin binding,
protein heterodimerization activity,
protein homodimerization activity,
metal ion binding,
transcription factor binding,
calmodulin binding,
actin filament binding		 plasma membrane,
cytosol,
F-actin capping protein complex,
nucleus		 positive regulation of protein binding,
actin filament bundle assembly,
barbed-end actin filament capping
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 445 HSFQKQQREKTRWLNSGRGDE ROCK1 10209029
LTP
1.00
 - -
0.70
 - medium

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cell adhesion molecule binding,
actin filament binding		 filopodium,
cortical cytoskeleton,
actin filament,
cytosol,
ruffle membrane,
microvillus membrane,
extrinsic to membrane,
apical plasma membrane		 membrane to membrane docking,
regulation of cell shape,
actin filament bundle assembly,
cytoskeletal anchoring at plasma membrane,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 567 NMRQGRDKYKTLRQIRQGNTK ROCK1 10970850
LTP
0.95
 - ERM
0.76
 --
T 567 NMRQGRDKYKTLRQIRQGNTK ROCK1 19255442
LTP
0.95
 - ERM
0.76
 --
T 567 NMRQGRDKYKTLRQIRQGNTK ROCK1 19386264
LTP
0.95
 - ERM
0.76
 --

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17602   LYN_HUMAN
MINT-74938   BCAR1_HUMAN
MINT-3381308   SRC_HUMAN
MINT-6794892   PTN1_HUMAN
MINT-7294020   P53_HUMAN
MINT-7385708   SRC_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
SH2 domain binding,
signal transducer activity		 focal adhesion,
cytosol,
cytoskeleton		 signal complex assembly,
integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 732 SPRSSEGFYPSPQHMVQTNHY ROCK1 16760434
LTP
0.24
 - -
0.69
 --

Substrate: GFAP (glial fibrillary acidic protein, astrocyte (GFAP) (from PhosphoBase))
Seq-ID: P14136 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-66480   PDLI1_HUMAN
MINT-66672   PDLI7_HUMAN
MINT-66894   VIME_HUMAN
MINT-68330   CEP76_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of cytoskeleton intermediate filament,
cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 7     MERRRITSAARRSYVSS ROCK1 9099667
LTP
0.10
 - Filament_head
0.47
 - low
T 7     MERRRITSAARRSYVSS ROCK1 12686604
LTP
0.10
 - Filament_head
0.47
 - low
S 13 RRRITSAARRSYVSSGEMMVG ROCK1 9099667
LTP
0.38
 - Filament_head
0.42
 - low
S 13 RRRITSAARRSYVSSGEMMVG ROCK1 12686604
LTP
0.38
 - Filament_head
0.42
 - low
S 38 GRRLGPGTRLSLARMPPPLPT ROCK1 9099667
LTP
0.88
 - Filament_head
0.63
 - low
S 38 GRRLGPGTRLSLARMPPPLPT ROCK1 12686604
LTP
0.88
 - Filament_head
0.63
 - low

Substrate: MARCKS (Protein kinase C substrate)
Seq-ID: P26645 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
actin binding,
calmodulin binding		 centrosome,
cell cortex,
membrane,
germinal vesicle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 152 ETPKKKKKRFSFKKSFKLSGF ROCK1 15708490
LTP
1.00
 - MARCKS
0.51
 - medium

Substrate: Myosin regulatory light chain 2, smooth muscle (myosin regulatory light chain 2, smooth muscle major isoform (from PhosphoBase))
Seq-ID: P19105 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48063   IKKA_HUMAN
MINT-48126   IKKE_HUMAN
MINT-48240   NEMO_HUMAN
MINT-48521   M3K3_HUMAN
MINT-48689   NFKB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
motor activity,
protein binding		 myosin complex
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 18 TKTKKRPQRATSNVFAMFDQS ROCK1 12185584
LTP
0.90
 - -
0.55
 - medium
S 19 KTKKRPQRATSNVFAMFDQSQ ROCK1 12185584
LTP
0.94
 - -
0.54
 - medium

Substrate: Protein phosphatase 1, regulatory subunit 12A (Myosin phosphatase target subunit 1)
Seq-ID: O14974 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48483   M3K3_HUMAN
MINT-72807   MPRIP_HUMAN
MINT-7247014   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity,
protein binding		 cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 696 SRQARQSRRSTQGVTLTDLQE ROCK1 11384979
LTP
1.00
 - -
0.79
 - medium
T 696 SRQARQSRRSTQGVTLTDLQE ROCK1 11719507
LTP
1.00
 - -
0.79
 - medium

Substrate: Protein phosphatase 1, regulatory subunit 12A (Myosin phosphatase target subunit 1)
Seq-ID: Q10728 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoprotein phosphatase activity,
protein binding		 cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 697 SRQARQSRRSTQGVTLTDLQE ROCK1 12359219
LTP
1.00
 - -
0.78
 - medium
T 697 SRQARQSRRSTQGVTLTDLQE ROCK1 10579722
LTP
1.00
 - -
0.78
 - medium
S 854 ERRRPREKRRSTGVSFWTQDS ROCK1 12359219
LTP
1.00
 - -
0.64
 - medium
S 854 ERRRPREKRRSTGVSFWTQDS ROCK1 10579722
LTP
1.00
 - -
0.64
 - medium

Substrate: PTEN (Lipid phosphatase)
Seq-ID: P60484 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity,
protein tyrosine phosphatase activity,
phosphatidylinositol-3-phosphatase activity,
lipid binding,
protein serine/threonine phosphatase activity,
protein tyrosine/serine/threonine phosphatase activity,
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity,
enzyme binding,
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity,
PDZ domain binding		 cytosol,
nucleus		 protein stabilization,
inositol phosphate dephosphorylation,
central nervous system development,
regulation of cyclin-dependent protein kinase activity,
regulation of neuron projection development,
apoptosis,
positive regulation of transcription factor activity,
protein amino acid dephosphorylation,
canonical Wnt receptor signaling pathway,
phosphoinositide dephosphorylation,
negative regulation of cell migration,
induction of apoptosis,
negative regulation of focal adhesion assembly,
negative regulation of protein kinase B signaling cascade,
cell proliferation,
negative regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 229 QLKVKIYSSNSGPTRREDKFM ROCK1 15793569
LTP
0.58
 - PTEN_C2
0.21
 1D5R 41.80%
T 232 VKIYSSNSGPTRREDKFMYFE ROCK1 15793569
LTP
0.05
 - PTEN_C2
0.21
 1D5R 50.00%

Substrate: SOX9 (specific RNA polymerase II transcription fa...)
Seq-ID: P48436 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
specific RNA polymerase II transcription factor activity nucleus transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 181 DYKYQPRRRKSVKNGQAEAEE ROCK1 20039424
LTP
0.98
 MOD_PKA_1
 - -
0.82
 - medium

Substrate: Vimentin (vimentin (from PhosphoBase))
Seq-ID: P08670 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
structural constituent of cytoskeleton		 intermediate filament,
cytosol		 cellular component movement,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 72 ATRSSAVRLRSSVPGVRLLQD ROCK1 9565595
LTP
0.90
 - Filament_head
0.38
 --

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