List of substrates found:


Substrate: Alpha-actinin 1 (F-actin cross linking protein)
Seq-ID: P12814 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-45875   KCC2A_HUMAN
MINT-45879   KCC2A_RAT
MINT-72665   HS90B_HUMAN
MINT-2856533   ATX2_HUMAN
MINT-2856571   COIL_HUMAN
MINT-6795322   SRC_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
vinculin binding,
actin binding,
integrin binding		 focal adhesion,
pseudopodium,
cytosol,
nucleolus,
actin cytoskeleton,
Z disc		 regulation of apoptosis,
negative regulation of cellular component movement,
focal adhesion assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 12 DHYDSQQTNDYMQPEEDWDRD FAK 11369769
LTP
0.78
 - -
0.55
 --

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17602   LYN_HUMAN
MINT-74938   BCAR1_HUMAN
MINT-3381308   SRC_HUMAN
MINT-6794892   PTN1_HUMAN
MINT-7294020   P53_HUMAN
MINT-7385708   SRC_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
SH2 domain binding,
signal transducer activity		 focal adhesion,
cytosol,
cytoskeleton		 signal complex assembly,
integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
 Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2		 -
0.49
 --
Y 576 GLSRYMEDSTYYKASKGKLPI FAK 7529876
LTP
1.00
 - TyrKc
0.11
 2J0L 96.51%
Y 577 LSRYMEDSTYYKASKGKLPIK FAK 7529876
LTP
1.00
 - TyrKc
0.11
 2J0L 25.33%

Substrate: N-WASP (Cytoskeletal binding protein)
Seq-ID: Q91YD9 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
small GTPase regulator activity,
actin binding		 cytoplasm,
lamellipodium,
actin cytoskeleton		 protein complex assembly,
actin polymerization or depolymerization,
transcription,
actin nucleation,
regulation of transcription,
response to bacterium
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 253 LKDRETSKVIYDFIEKTGGVE FAK 14676198
LTP
1.00
 - PBD
0.67
 - low

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: Q61140 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19527   FYN_MOUSE
MINT-58759   LYN_MOUSE
MINT-6763504   PTN1_HUMAN
MINT-7303491   FAK1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding focal adhesion,
membrane fraction,
cytoplasm,
lamellipodium,
ruffle		 B cell receptor signaling pathway,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
platelet-derived growth factor receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 668 ENSEGGWMEDYDYVHLQGKEE FAK 11604500
LTP
1.00
 - -
0.49
 - low

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49023 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1953339   GIT1_HUMAN
MINT-1953360   GIT2_HUMAN
MINT-6169431   CSK_HUMAN
MINT-6169440   PTN11_HUMAN
MINT-6169502   GAB1_HUMAN
MINT-6763928   CRK_HUMAN
MINT-7145479   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
vinculin binding,
zinc ion binding		 focal adhesion,
cytoplasm,
microtubule associated complex,
lamellipodium		 muscle contraction,
signal complex assembly,
signal transduction,
cell-matrix adhesion,
cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 7537852
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 12408869
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7537852
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49024 [Gallus gallus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
zinc ion binding focal adhesion,
cytoplasm,
cytoskeleton
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 118 SPRASEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.71
 - Paxillin
0.83
 - low

Substrate: SH3-containing GRB2-like protein 1 (Possible regulatory role in synaptic vesicle recycling)
Seq-ID: Q99961 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18018   SH3K1_HUMAN
MINT-7103074   KCMA1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
lipid binding,
protein binding		 early endosome membrane central nervous system development,
signal transduction,
endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PLDQPSCKALYDFEPENDGEL FAK 16054026
LTP
0.98
 - SH3
0.56
 - low

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