List of substrates found:


Substrate: Alpha adducin (Structural protein)
Seq-ID: P35611 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-72730   RFX1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
spectrin binding,
protein heterodimerization activity,
protein homodimerization activity,
metal ion binding,
transcription factor binding,
calmodulin binding,
actin filament binding		 plasma membrane,
cytosol,
F-actin capping protein complex,
nucleus		 positive regulation of protein binding,
actin filament bundle assembly,
barbed-end actin filament capping
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 445 HSFQKQQREKTRWLNSGRGDE ROCK_group 10209029
LTP
1.00
 - -
0.70
 - medium
T 480 TKWTKEDGHRTSTSAVPNLFV ROCK_group 10209029
LTP
0.55
 - -
0.61
 - medium

Substrate: Desmin (desmin (from PhosphoBase))
Seq-ID: P17661 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of cytoskeleton,
protein binding		 Z disc muscle contraction,
regulation of heart contraction,
cytoskeleton organization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 17 SSQRVSSYRRTFGGAPGFPLG ROCK_group 10574968
LTP
0.25
 - Filament_head
0.45
 - medium
T 76 LGSLRASRLGTTRTPSSYGAG ROCK_group 10574968
LTP
0.00
 - Filament_head
0.53
 - medium
T 77 GSLRASRLGTTRTPSSYGAGE ROCK_group 10574968
LTP
0.23
 - Filament_head
0.52
 - medium

Substrate: Desmin (desmin (from PhosphoBase))
Seq-ID: P31001 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of cytoskeleton sarcolemma,
synapse,
insoluble fraction,
Z disc		 muscle organ development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 17 SSQRVSSYRRTFGGAPGFSLG ROCK_group 9875213
LTP
0.25
 - Filament_head
0.41
 - medium
T 76 LGSLRSSRLGTTRAPSYGAGE ROCK_group 9875213
LTP
0.02
 - Filament_head
0.48
 - medium
T 77 GSLRSSRLGTTRAPSYGAGEL ROCK_group 9875213
LTP
0.02
 - Filament_head
0.47
 - medium

Substrate: DRP-2 (Cytoskeletal associated protein)
Seq-ID: Q16555 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-6826109   RK_BOVIN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
dihydropyrimidinase activity,
protein binding		 microtubule cytoskeleton signal transduction,
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 555 QIDDNIPRRTTQRIVAPPGGR ROCK_group 10818093
LTP
0.21
 - -
0.74
 - medium

Substrate: GFAP (glial fibrillary acidic protein, astrocyte (GFAP) (from PhosphoBase))
Seq-ID: P14136 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-66480   PDLI1_HUMAN
MINT-66672   PDLI7_HUMAN
MINT-66894   VIME_HUMAN
MINT-68330   CEP76_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of cytoskeleton intermediate filament,
cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 7     MERRRITSAARRSYVSS ROCK_group 9099667
LTP
0.10
 - Filament_head
0.47
 - low
T 7     MERRRITSAARRSYVSS ROCK_group 12686604
LTP
0.10
 - Filament_head
0.47
 - low
S 13 RRRITSAARRSYVSSGEMMVG ROCK_group 9099667
LTP
0.38
 - Filament_head
0.42
 - low
S 13 RRRITSAARRSYVSSGEMMVG ROCK_group 12686604
LTP
0.38
 - Filament_head
0.42
 - low
S 38 GRRLGPGTRLSLARMPPPLPT ROCK_group 12686604
LTP
0.88
 - Filament_head
0.63
 - low

Substrate: LIM domain kinase 1 (Serine/threonine kinase)
Seq-ID: P53667 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2833254   MK14_HUMAN
MINT-2833388   MAPK2_HUMAN
MINT-6173989   COF1_HUMAN
MINT-7228333   KAPCA_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
heat shock protein binding,
zinc ion binding		 cytoplasm,
growth cone		 protein amino acid phosphorylation,
actin cytoskeleton organization,
positive regulation of actin filament bundle assembly,
Rho protein signal transduction,
negative regulation of ubiquitin-protein ligase activity,
positive regulation of axon extension
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 508 LKKPDRKKRYTVVGNPYWMAP ROCK_group 10652353
LTP
1.00
 - STYKc
0.29
 - medium

Substrate: LIM domain kinase 2 (Serine/threonine kinase)
Seq-ID: P53671 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61744   HIPK3_HUMAN
MINT-3380769   PARD3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
zinc ion binding,
protein binding		 mitochondrion,
nucleus		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 505 LRKNDRKKRYTVVGNPYWMAP ROCK_group 11018042
LTP
1.00
 - STYKc
0.25
 - low

Substrate: MARCKS (Protein kinase C substrate)
Seq-ID: P26645 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
actin binding,
calmodulin binding		 centrosome,
cell cortex,
membrane,
germinal vesicle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 160 RFSFKKSFKLSGFSFKKSKKE ROCK_group 14501149
LTP
1.00
 - MARCKS
0.46
 - medium

Substrate: Moesin (Adapter molecule)
Seq-ID: P26038 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of cytoskeleton,
cell adhesion molecule binding,
receptor binding		 filopodium,
cytoplasm,
cytoskeleton,
nucleolus,
microvillus membrane,
extrinsic to membrane,
apical plasma membrane		 membrane to membrane docking,
leukocyte cell-cell adhesion,
leukocyte migration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 558 NMRLGRDKYKTLRQIRQGNTK ROCK_group 9516463
LTP
0.98
 - ERM
0.69
 - medium
T 558 NMRLGRDKYKTLRQIRQGNTK ROCK_group 19255442
LTP
0.98
 - ERM
0.69
 - medium

Substrate: Nefl (Neurofilament protein L)
Seq-ID: P02548 [Bos taurus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
identical protein binding,
structural constituent of cytoskeleton		 neurofilament locomotion,
anterograde axon cargo transport,
axon regeneration in the peripheral nervous system,
positive regulation of axonogenesis,
negative regulation of neuron apoptosis,
regulation of axon diameter,
neurofilament bundle assembly,
axon transport of mitochondrion,
neuromuscular process controlling balance,
retrograde axon cargo transport,
microtubule cytoskeleton organization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 27 RYVETPRVHISSVRSGYSTAR ROCK_group 9571164
LTP
0.27
 - Filament_head
0.40
 - medium
S 58 SSSLSVRRSYSSSSGSLMPSL ROCK_group 9571164
LTP
0.13
 - Filament_head
0.40
 - medium

Substrate: Radixin (Cytoskeletal protein)
Seq-ID: P35241 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18849   GDIR1_HUMAN
MINT-4652127   ITB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
actin binding plasma membrane,
cytoskeleton,
Golgi apparatus,
extrinsic to membrane		 actin filament capping
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 564 NVKAGRDKYKTLRQIRQGNTK ROCK_group 9456324
LTP
0.98
 - ERM
0.76
 - low
T 573 KTLRQIRQGNTKQRIDEFEAM ROCK_group 9456324
LTP
0.90
 - ERM
0.71
 - low

Substrate: Vimentin (vimentin (from PhosphoBase))
Seq-ID: P08670 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
structural constituent of cytoskeleton		 intermediate filament,
cytosol		 cellular component movement,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 72 ATRSSAVRLRSSVPGVRLLQD ROCK_group 9565595
LTP
0.90
 - Filament_head
0.38
 --

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