List of substrates found:


Substrate: ATF4 (protein binding, specific RNA polymerase II transcription fa...)
Seq-ID: P18848 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-49644   RPB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein dimerization activity,
transcription activator activity,
specific RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity		 plasma membrane,
cytoplasm,
nucleus		 gluconeogenesis,
transcription,
cellular amino acid metabolic process,
response to endoplasmic reticulum stress,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 245 SPSTRGSPNRSLPSPGVLCGS RSK-2 15109498
LTP
0.96
 - -
0.76
 - medium

Substrate: ATF4 (protein binding, specific RNA polymerase II transcription fa...)
Seq-ID: Q06507 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein dimerization activity,
transcription activator activity,
specific RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity		 plasma membrane,
cytoplasm,
transcription factor complex		 gluconeogenesis,
transcription,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 251 PPDNLPSPGGSRGSPRPKPYD RSK-2 15109498
LTP
0.90
 - -
0.94
 - low

Substrate: BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID: Q92934 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14699   B2CL1_HUMAN
MINT-66103   1433S_HUMAN
MINT-7034091   B2L11_HUMAN
MINT-7717137   NAF1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding cytosol,
mitochondrial outer membrane		 induction of apoptosis by extracellular signals,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 75 GAVEIRSRHSSYPAGTEDDEG RSK-2 10558990
LTP
0.32
 MOD_PKA_2
 - Bcl-2_BAD
0.83
 - medium

Substrate: CREB (cAMP response element binding protein (CREB).)
Seq-ID: P16220 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
transcription cofactor activity		 protein amino acid phosphorylation,
signal transduction,
interspecies interaction between organisms,
response to organic substance
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 133 KRREILSRRPSYRKILNDLSS RSK-2 11698596
LTP
1.00
 - pKID
0.54
 - low

Substrate: Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))
Seq-ID: P46527 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity,
transforming growth factor beta receptor, cytoplasmic mediator activity,
protein binding		 cytosol,
nucleus		 negative regulation of kinase activity,
regulation of cyclin-dependent protein kinase activity,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
G1/S transition of mitotic cell cycle,
autophagic cell death,
cellular response to lithium ion,
induction of apoptosis,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 198 PKKPGLRRRQT           RSK-2 14504289
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --

Substrate: DAP kinase 1 (Serine/threonine kinase)
Seq-ID: P53355 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-7014569   BECN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
calmodulin binding		 cytoplasm,
actin cytoskeleton		 induction of apoptosis by extracellular signals,
protein amino acid phosphorylation,
apoptosis,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 289 DTQQALSRKASAVNMEKFKKF RSK-2 16213824
LTP
1.00
 - -
0.37
 - medium

Substrate: Fos (Transcription factor)
Seq-ID: P01100 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-68804   JUN_HUMAN
MINT-68820   VE7_HPV16
MINT-1788374   JUNB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
R-SMAD binding,
specific RNA polymerase II transcription factor activity,
promoter binding,
sequence-specific DNA binding transcription factor activity		 DNA methylation,
inflammatory response,
SMAD protein signal transduction,
transforming growth factor beta receptor signaling pathway,
cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 362 PSCAAAHRKGSSSNEPSSDSL RSK-2 9920881
LTP
1.00
 - -
0.58
 - low
S 362 PSCAAAHRKGSSSNEPSSDSL RSK-2 11585927
LTP
1.00
 - -
0.58
 - low

Substrate: Myocyte-specific enhancer factor 2C (Myocyte-specific enhancer factor 2C)
Seq-ID: Q06413 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-49706   HDAC4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity,
protein binding		 nuclear speck negative regulation of gene-specific transcription from RNA polymerase II promoter,
nervous system development,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
transcription,
apoptosis,
positive regulation of survival gene product expression,
muscle organ development,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 192 MSPGVTHRPPSAGNTGGLMGG RSK-2 17630987
LTP
1.00
 - -
0.86
 --

Substrate: NFATC4 (transcription coactivator activity)
Seq-ID: Q14934 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7972976   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription coactivator activity,
sequence-specific DNA binding transcription factor activity		 cytoplasm,
nucleus		 transcription from RNA polymerase II promoter,
inflammatory response,
regulation of transcription, DNA-dependent,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 676 FYVSNGRRKRSPTQSFRFLPV RSK-2 15657420
LTP
1.00
 MOD_ProDKin_1
 - IPT
0.32
 --

Substrate: RRN3 (Transcription initiation factor)
Seq-ID: Q9NYV6 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4544044   SET_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nucleolus,
nucleoplasm		 transcription,
regulation of transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 649 GSPPVLYMQPSPL         RSK-2 12620228
LTP
0.00
 - -
0.40
 - medium

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