List of substrates found:


Substrate: ADAM 15 (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15)
Seq-ID: Q13444 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2792372   LYN_HUMAN
MINT-2792392   YES_HUMAN
MINT-2792412   FYN_HUMAN
MINT-2792521   PACN3_HUMAN
MINT-2792601   ARHG7_HUMAN
MINT-2792621   ARHG6_HUMAN
MINT-2792641   NCK1_HUMAN
MINT-2792681   SRBS1_HUMAN
MINT-2792701   SH3R3_HUMAN
MINT-2792950   SNX33_HUMAN
MINT-2792970   SPD2A_HUMAN
MINT-2793013   SRC_HUMAN
MINT-7218089   HCK_HUMAN
MINT-7218109   LCK_HUMAN
MINT-7218139   GRB2_HUMAN
MINT-7218198   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
metalloendopeptidase activity,
zinc ion binding		 acrosomal vesicle,
integral to membrane,
flagellum,
adherens junction,
endomembrane system		 proteolysis,
angiogenesis,
cell-matrix adhesion,
collagen catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 715 LLVLVMLGASYWYRARLHQRL SRC_group 11741929
LTP
0.30
 - TRANS
0.06
 - medium
Y 735 LCQLKGPTCQYRAAQSGPSER SRC_group 11741929
LTP
0.13
 - -
0.46
 - medium

Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 125 DMPVDPDNEAYEMPSEEGYQD SRC_group 12096713
LTP
0.26
 - Synuclein
0.82
 --

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein binding		 integral to membrane,
extracellular space		 male gonad development,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 900 LSPEHAPAEMYDIMKTCWDAD SRC_group 12878163
LTP
1.00
 PIK3R1 SH2 TyrKc
0.24
 1T46 16.16%

Substrate: Ephrin B1 (Ligand of receptor tyrosine kinase)
Seq-ID: O73612 [Gallus gallus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 312 CPHYEKVSGDYGHPVYIVQEM SRC_group 11983165
LTP
0.99
 - -
0.20
 - medium
Y 317 KVSGDYGHPVYIVQEMPPQSP SRC_group 11983165
LTP
0.99
 - -
0.29
 - medium
Y 331 EMPPQSPANIYYKV        SRC_group 11983165
LTP
1.00
 - -
0.23
 - medium

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
cell migration,
integrin-mediated signaling pathway,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 193 PTLSTSAPQEYLYLHQCISRR SRC_group 12819203
LTP
0.93
 SHC_group SH2 -
0.41
 - medium
Y 603 APKKSTGSVDYLALDFQPGSP SRC_group 9885561
LTP
0.96
 PTPN11 SH2 -
0.70
 - medium

Substrate: PMCA4b (Catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.)
Seq-ID: P23634 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58323   NOS1_RAT
MINT-73076   DLG2_RAT
MINT-73077   DLG4_RAT
MINT-73082   DLG2_HUMAN
MINT-73083   DLG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
ATP binding,
calcium-transporting ATPase activity,
calmodulin binding,
protein binding		 integral to plasma membrane ATP biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1212 VLLLDGEVTPYANTNNNAVDC SRC_group 12540962
LTP
0.00
 - -
0.47
 - medium
Y 1212 VLLLDGEVTPYANTNNNAVDC SRC_group 9182531
LTP
0.00
 - -
0.47
 - medium

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