List of substrates found:


Substrate: IL-13R-alpha-1 (Transmenbrane receptor)
Seq-ID: O09030 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 402 DTLHWKKYDIYEKQSKEETDS Tyk2 10409622
LTP
0.89
 - -
0.24
 - medium

Substrate: INF-alpha REC (Interferon receptor)
Seq-ID: P17181 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-73134   TYK2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
type I interferon receptor activity integral to plasma membrane blood coagulation,
JAK-STAT cascade,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8605876
LTP
1.00
 STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2		 -
0.03
 - low
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8700538
LTP
1.00
 STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2		 -
0.03
 - low
Y 481 SLKPSSSIDEYFSEQPLKNLL Tyk2 7526154
LTP
1.00
 STAT2 SH2;
TYK2 SH2		 -
0.24
 - low

Substrate: Interleukin-10 receptor alpha chain precursor (Type II cytokine receptor family)
Seq-ID: Q13651 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
interleukin-10 receptor activity plasma membrane,
integral to membrane		 blood coagulation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 446 EDPAAVAFQGYLRQTRCAEEK Tyk2 10433356
LTP
1.00
 - -
0.51
 - medium
Y 496 GLHPPALAKGYLKQDPLEMTL Tyk2 10433356
LTP
1.00
 - -
0.51
 - medium

Substrate: RACK1 (Adapter molecule)
Seq-ID: P63244 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48160   NEMO_HUMAN
MINT-68273   T22D4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein phosphatase binding,
receptor binding		 plasma membrane,
neuronal cell body,
cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 194 LKTNHIGHTGYLNTVTVSPDG Tyk2 15240704
LTP
0.98
 - WD40
0.28
 --

Substrate: Tyk2 (Cytoplasmic tyrosine kinase)
Seq-ID: P29597 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-73134   INAR1_HUMAN
MINT-4507312   KPCA_HUMAN
MINT-6793782   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Janus kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding		 cytoplasm,
cytoskeleton,
nucleus,
membrane		 peptidyl-tyrosine phosphorylation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1054 LAKAVPEGHEYYRVREDGDSP Tyk2 8702790
LTP
1.00
 - TyrKc
0.26
 - medium
Y 1055 AKAVPEGHEYYRVREDGDSPV Tyk2 8702790
LTP
1.00
 - TyrKc
0.24
 - medium

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