List of substrates found:


Substrate: IL-13R-alpha-1 (Transmenbrane receptor)
Seq-ID: O09030 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
integral to membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 402 DTLHWKKYDIYEKQSKEETDS Tyk2 10409622
LTP
0.89
- -
0.24
- medium

Substrate: INF-alpha REC (Interferon receptor)
Seq-ID: P17181 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8605876
LTP
1.00
STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2
-
0.03
- low
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8700538
LTP
1.00
STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2
-
0.03
- low
Y 481 SLKPSSSIDEYFSEQPLKNLL Tyk2 7526154
LTP
1.00
STAT2 SH2;
TYK2 SH2
-
0.24
- low

Substrate: Interleukin-10 receptor alpha chain precursor (Type II cytokine receptor family)
Seq-ID: Q13651 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
interleukin-10 receptor activity plasma membrane,
integral to membrane
blood coagulation
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 446 EDPAAVAFQGYLRQTRCAEEK Tyk2 10433356
LTP
1.00
- -
0.51
- medium
Y 496 GLHPPALAKGYLKQDPLEMTL Tyk2 10433356
LTP
1.00
- -
0.51
- medium

Substrate: RACK1 (Adapter molecule)
Seq-ID: P63244 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein phosphatase binding,
receptor binding
plasma membrane,
neuronal cell body,
cytoplasm
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 194 LKTNHIGHTGYLNTVTVSPDG Tyk2 15240704
LTP
0.98
- WD40
0.28
--

Substrate: Tyk2 (Cytoplasmic tyrosine kinase)
Seq-ID: P29597 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1054 LAKAVPEGHEYYRVREDGDSP Tyk2 8702790
LTP
1.00
- TyrKc
0.26
- medium
Y 1055 AKAVPEGHEYYRVREDGDSPV Tyk2 8702790
LTP
1.00
- TyrKc
0.24
- medium

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