List of substrates found:


Substrate: Dual specificity phosphatase 3 (Dual specificity phosphatase)
Seq-ID: P51452 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein tyrosine/serine/threonine phosphatase activity,
MAP kinase phosphatase activity		 cytosol,
immunological synapse,
nucleoplasm		 negative regulation of T cell activation,
inactivation of MAPK activity,
positive regulation of mitotic cell cycle,
negative regulation of T cell receptor signaling pathway,
peptidyl-tyrosine dephosphorylation,
negative regulation of JNK cascade,
negative regulation of ERK1 and ERK2 cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 138 YSRSPTLVIAYLMMRQKMDVK ZAP70 12447358
LTP
1.00
 - DSPc
0.17
 1VHR 3.93%

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14688   SHC1_HUMAN
MINT-56633   MK03_HUMAN
MINT-68496   P85A_HUMAN
MINT-7220613   GRB2_HUMAN
MINT-7300434   1433B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
 PTPN11 SH2;
SHC1 SH2		 -
0.69
 - low

Substrate: HIP55 (Adapter molecule)
Seq-ID: Q9UJU6 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-68272   SH24A_HUMAN
MINT-4563345   3BP2_HUMAN
MINT-7306062   SHAN3_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
enzyme activator activity,
identical protein binding,
actin binding		 cytosol,
lamellipodium,
cytoskeleton,
cell cortex		 activation of JUN kinase activity,
Rac protein signal transduction,
endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 334 CLVQAEEEAVYEEPPEQETFY ZAP70 14557276
LTP
0.14
 - -
0.71
 - medium
Y 344 YEEPPEQETFYEQPPLVQQQG ZAP70 14557276
LTP
1.00
 - -
0.79
 - medium

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O54957 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
receptor signaling protein activity		 integral to plasma membrane,
immunological synapse		 calcium-mediated signaling,
integrin-mediated signaling pathway,
gene expression,
cellular defense response,
inflammatory response,
mast cell degranulation,
regulation of T cell activation,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 136 DEDEDDYPNGYLVVLPDSSPA ZAP70 11368773
LTP
0.00
 PLCG_group SH2 -
0.77
 - low
Y 136 DEDEDDYPNGYLVVLPDSSPA ZAP70 11457888
LTP
0.00
 PLCG_group SH2 -
0.77
 - low
Y 175 SAFSVESCEDYVNVPESEESA ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.71
 - low
Y 195 AEASLDGSREYVNVSPEQQPV ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.83
 - low
Y 235 EGVDGEEAPDYENLQELN    ZAP70 11368773
LTP
1.00
 GRB2 SH2;
VAV_group SH2		 -
0.90
 - low

Substrate: LNK (Adapter molecule)
Seq-ID: Q9UQQ2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74566   EGFR_HUMAN
MINT-74567   ERBB2_HUMAN
MINT-74569   ERBB3_HUMAN
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
signal transducer activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 273 CTRLEMPDNLYTFVLKVKDRT ZAP70 9169414
LTP
0.03
 - PH
0.22
 - medium

Substrate: Mitogen-activated protein kinase 14 (Mitogen-activated protein kinase 14)
Seq-ID: Q16539 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17884   TAB1_HUMAN
MINT-64844   FKBP8_HUMAN
MINT-66629   TISB_HUMAN
MINT-2833254   LIMK1_HUMAN
MINT-2834463   NCOA3_HUMAN
MINT-4300259   MP2K3_HUMAN
MINT-4300277   MP2K6_HUMAN
MINT-4793793   RB_HUMAN
MINT-7557394   ATG9A_HUMAN
MINT-7973662   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
MP kinase activity,
MAP kinase kinase activity,
ATP binding,
protein binding		 cytosol,
nucleoplasm		 protein amino acid phosphorylation,
response to stress,
cellular component movement,
chemotaxis,
cell surface receptor linked signaling pathway,
Ras protein signal transduction,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 323 DPDDEPVADPYDQSFESRDLL ZAP70 15735648
LTP
0.84
 - -
0.52
 2FST 9.17%

Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13959   DDR2_HUMAN
MINT-14688   GAB2_HUMAN
MINT-15243   LYN_HUMAN
MINT-15425   FYN_HUMAN
MINT-15946   FCGR1_HUMAN
MINT-16179   SHIP1_HUMAN
MINT-16513   LCP2_HUMAN
MINT-17269   SRC_CHICK
MINT-17501   P85A_HUMAN
MINT-49636   CADH5_HUMAN
MINT-49637   VGFR2_HUMAN
MINT-49660   A4_HUMAN
MINT-60978   CBL_HUMAN
MINT-60980   ZAP70_HUMAN
MINT-60981   RET_HUMAN
MINT-61536   ERBB4_HUMAN
MINT-61537   GRB2_HUMAN
MINT-74732   EGFR_HUMAN
MINT-74737   ERBB2_HUMAN
MINT-74738   ERBB3_HUMAN
MINT-1782423   SOS1_HUMAN
MINT-2738306   JAK2_MOUSE
MINT-7714840   IQGA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
phospholipid binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 mitochondrial matrix,
Shc-EGFR complex,
cytosol		 positive regulation of DNA replication,
positive regulation of cell proliferation,
regulation of growth,
regulation of epidermal growth factor receptor activity,
epidermal growth factor receptor signaling pathway,
activation of MAPK activity,
Ras protein signal transduction,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 349 EEEEEPPDHQYYNDFPGKEPP ZAP70 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL ZAP70 9710204
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 427 PGRELFDDPSYVNVQNLDKAR ZAP70 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA ZAP70 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 126 DCLRDAMVRDYVRQTWKLEGE ZAP70 7961936
LTP
0.96
 - -
0.16
 2OQ1 39.30%
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 8756661
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 7961936
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%

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