Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

40S ribosomal protein S6
eIF-4B
mTOR
POLDIP3
Ribosomal protein S6 kinase 1

40S ribosomal protein S6 (40S ribosomal protein S6 (phosphoprotein NP33) (from PhosphoBase))

Seq-ID:

P62753 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-48303   M3K1_HUMAN
MINT-48824   M3K14_HUMAN
MINT-72675   HS90B_HUMAN
MINT-2833465   KS6A2_HUMAN
MINT-2833483   KS6B2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of ribosome, protein binding	nucleolus, cytosolic small ribosomal subunit	TOR signaling cascade, ribosomal small subunit biogenesis, glucose homeostasis, rRNA processing, positive regulation of apoptosis, translational elongation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	235	QEQIAKRRRLSSLRASTSKSE	p70S6K	17360704	LTP	0.59		-	COIL	0.73	-	medium
S	236	EQIAKRRRLSSLRASTSKSES	p70S6K	17360704	LTP	0.42		-	COIL	0.74	-	medium

eIF-4B (Translation regulatory protein)

Seq-ID:

P23588 [Homo sapiens]

Download:

Interaction Network(s):

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-18196   EIF3A_HUMAN
MINT-2793474   KS6A1_HUMAN
MINT-6538652   KCC2D_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, translation initiation factor activity, RNA binding	eukaryotic translation initiation factor 4F complex, cytosol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	422	TQERERSRTGSESSQTGTSTT	p70S6K	15071500	LTP	1.00		-	-	0.94	-	-

mTOR (Cell cycle control protein)

Seq-ID:

P42345 [Homo sapiens]

Download:

Interaction Network(s):

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-13782   4EBP1_MOUSE
MINT-16737   AKT1_HUMAN
MINT-17466   PDPK1_HUMAN
MINT-3307838   1433Z_HUMAN
MINT-7222784   P53_HUMAN
MINT-7222793   Q8N6M7_HUMAN
MINT-7556099   RPTOR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, phosphoprotein binding	Golgi membrane, TORC1 complex, TORC2 complex, phosphoinositide 3-kinase complex, mitochondrial outer membrane, endoplasmic reticulum membrane	TOR signaling cascade, response to amino acid stimulus, cell growth, peptidyl-serine phosphorylation, response to nutrient, protein amino acid autophosphorylation, protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	2446	TKGNKRSRTRTDSYSAGQSVE	p70S6K	15905173	LTP	0.11	MOD_PKB_1	-	PI3Kc	0.60	-	medium
S	2448	GNKRSRTRTDSYSAGQSVEIL	p70S6K	15905173	LTP	0.20	MOD_PKB_1	-	PI3Kc	0.52	-	medium

POLDIP3 (DNA polymerase interaction protein)

Seq-ID:

Q9BY77 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

-

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, RNA binding, protein binding	cytoplasm, nuclear speck	positive regulation of translation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	383	KESELPRRVNSASSSNPPAEV	p70S6K	15341740	LTP	0.24		-	-	0.77	-	medium

Ribosomal protein S6 kinase 1 (p70 S6 kinase)

Seq-ID:

P23443 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-14377   PDPK1_HUMAN
MINT-14953   4EBP1_MOUSE
MINT-15213   AKT1_HUMAN
MINT-15292   CDC42_HUMAN
MINT-51122   COASY_HUMAN
MINT-74872   TAU_HUMAN
MINT-74874   TAU_HUMAN
MINT-3390512   PDK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein kinase activity, protein binding	cell junction, cytoplasm, cytosol, synapse, mitochondrial outer membrane, synaptosome, nucleus	TOR signaling cascade, negative regulation of apoptosis, positive regulation of mitotic cell cycle, apoptosis, G1/S transition of mitotic cell cycle, phosphoinositide-mediated signaling, positive regulation of translational initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	412	ESANQVFLGFTYVAPSVLESV	p70S6K	15388791	LTP	0.94		-	S_TK_X	0.23	-	low
T	412	ESANQVFLGFTYVAPSVLESV	p70S6K	12183455	LTP	0.94		-	S_TK_X	0.23	-	low