List of substrates found:


Substrate: eIF4E-binding protein 1 (Eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I))
Seq-ID: Q13541 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19057   IF4E_HUMAN
MINT-64139   ERG19_HUMAN
MINT-6549354   RPTOR_HUMAN
MINT-7021879   HS90B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol TOR signaling cascade,
positive regulation of mitotic cell cycle,
G1/S transition of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 37 VQLPPGDYSTTPGGTLFSTTP mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.83
 - medium
T 46 TTPGGTLFSTTPGGTRIIYDR mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.62
 - medium
S 65 DRKFLMECRNSPVTKTPPRDL mTOR 12912989
LTP
1.00
 - eIF_4EBP
0.67
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.80
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG mTOR 12912989
LTP
1.00
 - eIF_4EBP
0.80
 - medium
S 83 RDLPTIPGVTSPSSDEPPMEA mTOR 9405468
LTP
0.20
 - eIF_4EBP
0.93
 - medium
S 101 MEASQSHLRNSPEDKRAGGEE mTOR 12912989
LTP
0.17
 - eIF_4EBP
0.92
 - medium

Substrate: mTOR (Cell cycle control protein)
Seq-ID: P42345 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13782   4EBP1_MOUSE
MINT-16737   AKT1_HUMAN
MINT-17466   PDPK1_HUMAN
MINT-3307838   1433Z_HUMAN
MINT-7222784   P53_HUMAN
MINT-7222793   Q8N6M7_HUMAN
MINT-7556099   RPTOR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
phosphoprotein binding		 Golgi membrane,
TORC1 complex,
TORC2 complex,
phosphoinositide 3-kinase complex,
mitochondrial outer membrane,
endoplasmic reticulum membrane		 TOR signaling cascade,
response to amino acid stimulus,
cell growth,
peptidyl-serine phosphorylation,
response to nutrient,
protein amino acid autophosphorylation,
protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 2481 TGTTVPESIHSFIGDGLVKPE mTOR 10702316
LTP
0.04
 - PI3Kc
0.38
 - medium

Substrate: PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))
Seq-ID: P31750 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4049581   PDE3A_MOUSE
MINT-6175057   STK4_HUMAN
MINT-6793722   PTN1_HUMAN
MINT-6978911   HS90A_MOUSE
MINT-6978941   UBIQ_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 plasma membrane,
spindle,
cytosol,
lamellipodium,
nucleus		 response to food,
glycogen cell development involved in embryonic placenta development,
protein ubiquitination,
regulation of neuron projection development,
maternal placenta development,
glycogen biosynthetic process,
apoptotic mitochondrial changes,
germ cell development,
inflammatory response,
insulin-like growth factor receptor signaling pathway,
peptidyl-serine phosphorylation,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
anagen,
positive regulation of sodium ion transport,
regulation of translation,
labyrinthine layer blood vessel development,
protein catabolic process,
protein kinase B signaling cascade,
glucose transport,
insulin receptor signaling pathway,
regulation of survival gene product expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 473 SERRPHFPQFSYSASGTA    mTOR 16221682
LTP
0.95
 - S_TK_X
0.53
 - medium

Substrate: Ribosomal protein S6 kinase 1 (p70 S6 kinase)
Seq-ID: P23443 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14377   PDPK1_HUMAN
MINT-14953   4EBP1_MOUSE
MINT-15213   AKT1_HUMAN
MINT-15292   CDC42_HUMAN
MINT-51122   COASY_HUMAN
MINT-74872   TAU_HUMAN
MINT-74874   TAU_HUMAN
MINT-3390512   PDK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
protein kinase activity,
protein binding		 cell junction,
cytoplasm,
cytosol,
synapse,
mitochondrial outer membrane,
synaptosome,
nucleus		 TOR signaling cascade,
negative regulation of apoptosis,
positive regulation of mitotic cell cycle,
apoptosis,
G1/S transition of mitotic cell cycle,
phosphoinositide-mediated signaling,
positive regulation of translational initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 390 SQFDSKFTRQTPVDSPDDSTL mTOR 12370290
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL mTOR 14560963
LTP
0.84
 - S_TK_X
0.66
 - low
S 394 SKFTRQTPVDSPDDSTLSESA mTOR 11914378
LTP
0.98
 - S_TK_X
0.70
 - low
T 412 ESANQVFLGFTYVAPSVLESV mTOR 15809305
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV mTOR 15718470
LTP
0.94
 - S_TK_X
0.23
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT mTOR 15809305
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW mTOR 11914378
LTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low

Substrate: Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)
Seq-ID: Q9UBS0 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 nucleoplasm positive regulation of translational initiation,
translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 388 ESANQAFLGFTYVAPSVLDSI mTOR 14560963
LTP
0.93
 - S_TK_X
0.32
 - medium

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