Substrate: Alpha-synuclein (Chaperone)
Seq-ID: O55042 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
identical protein binding,
arachidonic acid binding		 plasma membrane,
cytosol,
synaptosome,
nucleus		 dopamine biosynthetic process,
synaptic transmission, dopaminergic,
regulation of dopamine secretion,
regulation of macrophage activation,
response to drug,
microglial cell activation,
regulation of glutamate secretion,
mitochondrial membrane organization,
adult locomotory behavior,
fatty acid metabolic process,
synaptic vesicle endocytosis,
negative regulation of neuron apoptosis,
cellular response to oxidative stress,
long-term synaptic potentiation,
regulation of locomotion,
phospholipid metabolic process,
regulation of acyl-CoA biosynthetic process,
regulation of long-term neuronal synaptic plasticity,
regulation of excitatory postsynaptic membrane potential,
mitochondrial ATP synthesis coupled electron transport,
positive regulation of neurotransmitter secretion,
neutral lipid metabolic process
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 129 DPGSEAYEMPSEEGYQDYEPE - 15304353
LTP
0.55
 - Synuclein
0.80
 - medium

Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 87 VAQKTVEGAGSIAAATGFVKK - 10617630
LTP
0.10
 - Synuclein
0.39
 --
S 87 VAQKTVEGAGSIAAATGFVKK DYRK1A 16959772
LTP
0.10
 - Synuclein
0.39
 --
Y 125 DMPVDPDNEAYEMPSEEGYQD SYK 11744621
LTP
0.26
 - Synuclein
0.82
 --
Y 125 DMPVDPDNEAYEMPSEEGYQD SRC_group 12096713
LTP
0.26
 - Synuclein
0.82
 --
Y 125 DMPVDPDNEAYEMPSEEGYQD Fyn 11162638
LTP
0.26
 - Synuclein
0.82
 --
Y 125 DMPVDPDNEAYEMPSEEGYQD - 12893833
LTP
0.26
 - Synuclein
0.82
 --
S 129 DPDNEAYEMPSEEGYQDYEPE CK2_alpha 10617630
LTP
0.09
 - Synuclein
0.84
 --
S 129 DPDNEAYEMPSEEGYQDYEPE CK1_alpha 10617630
LTP
0.09
 - Synuclein
0.84
 --
S 129 DPDNEAYEMPSEEGYQDYEPE GRK-2 10852916
LTP
0.09
 - Synuclein
0.84
 --
S 129 DPDNEAYEMPSEEGYQDYEPE GRK-5 10852916
LTP
0.09
 - Synuclein
0.84
 --
S 129 DPDNEAYEMPSEEGYQDYEPE - 11813001
LTP
0.09
 - Synuclein
0.84
 --
Y 133 EAYEMPSEEGYQDYEPEA    SYK 11744621
LTP
0.12
 - -
0.80
 --
Y 136 EMPSEEGYQDYEPEA       SYK 11744621
LTP
0.20
 - -
0.81
 --

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