Substrate: Beta-ARK-1 (Beta-adrenergic receptor kinase)
Seq-ID: P25098 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51490   EGFR_HUMAN
MINT-3376147   MDM2_HUMAN
MINT-6608788   GIT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
G-protein coupled receptor kinase activity,
ATP binding,
Edg-2 lysophosphatidic acid receptor binding,
alpha-2A adrenergic receptor binding,
beta-adrenergic receptor kinase activity,
signal transducer activity		 cytosol,
soluble fraction		 negative regulation of striated muscle contraction,
desensitization of G-protein coupled receptor protein signaling pathway,
positive regulation of catecholamine secretion,
muscarinic acetylcholine receptor signaling pathway,
tachykinin receptor signaling pathway,
peptidyl-serine phosphorylation,
cardiac muscle contraction,
negative regulation of the force of heart contraction by chemical signal
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 29 KSKATPAARASKKILLPEPSI PKC_alpha 11042191
LTP
0.26
 - -
0.36
 1OMW 130.33%
S 670 RVPKMKNKPRSPVVELSKVPL MAPK_group 10727525
LTP
0.19
 MOD_ProDKin_1
 - -
0.44
 --
S 670 RVPKMKNKPRSPVVELSKVPL - 18088087
HTP
0.19
 MOD_ProDKin_1
 - -
0.44
 --
S 685 LSKVPLVQRGSANGL       PKA_group 11278469
LTP
0.26
 MOD_PKA_2
 - -
0.36
 --

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