Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
SH3/SH2 adaptor activity,
coreceptor activity		 external side of plasma membrane,
cytosol,
integral to plasma membrane		 regulatory T cell differentiation,
humoral immune response,
positive regulation of anti-apoptosis,
regulation of defense response to virus by virus,
positive regulation of interleukin-2 biosynthetic process,
positive regulation of viral genome replication,
cell surface receptor linked signaling pathway,
cytokine biosynthetic process,
positive regulation of mitosis,
positive regulation of T cell proliferation,
positive regulation of translation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 191 SKRSRLLHSDYMNMTPRRPGP ITK 8992971
LTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 191 SKRSRLLHSDYMNMTPRRPGP - 16094384
HTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 206 PRRPGPTRKHYQPYAPPRDFA - 8992971
LTP
0.13
 - -
0.47
 - medium
Y 206 PRRPGPTRKHYQPYAPPRDFA - 8946678
LTP
0.13
 - -
0.47
 - medium
Y 209 PGPTRKHYQPYAPPRDFAAYR ITK 8992971
LTP
1.00
 - -
0.36
 - medium
Y 209 PGPTRKHYQPYAPPRDFAAYR - 8946678
LTP
1.00
 - -
0.36
 - medium
Y 209 PGPTRKHYQPYAPPRDFAAYR - 15592455
HTP
1.00
 - -
0.36
 - medium
Y 209 PGPTRKHYQPYAPPRDFAAYR - 16094384
HTP
1.00
 - -
0.36
 - medium
Y 218 PYAPPRDFAAYRS         ITK 8992971
LTP
0.36
 - -
0.18
 - medium
Y 218 PYAPPRDFAAYRS         - 8946678
LTP
0.36
 - -
0.18
 - medium

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