Substrate: CD74 (CD antigen)
Seq-ID: P04233 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-7234499   CXCR4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-amyloid binding,
identical protein binding,
MHC class II protein binding,
cytokine receptor activity		 integral to membrane,
Golgi apparatus,
lysosome,
endoplasmic reticulum membrane		 positive regulation of fibroblast proliferation,
positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of ERK1 and ERK2 cascade,
positive regulation of B cell proliferation,
protein complex assembly,
negative regulation of apoptosis,
regulation of macrophage activation,
prostaglandin biosynthetic process,
antigen processing and presentation of endogenous antigen,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
intracellular protein transport,
negative regulation of peptide secretion,
cell proliferation,
immunoglobulin mediated immune response,
positive regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 25 PVMDDQRDLISNNEQLPMLGR - 2507633
LTP
0.28
 - MHC2-interact
0.65
 - medium
S 42 MLGRRPGAPESKCSRGALYTG - 2507633
LTP
0.23
 - MHC2-interact
0.51
 - medium
S 45 RRPGAPESKCSRGALYTGFSI - 2507633
LTP
0.91
 - MHC2-interact
0.41
 - medium

Substrate: CD74 (CD antigen)
Seq-ID: P04441 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
MHC class II protein binding,
cytokine receptor activity		 external side of plasma membrane,
integral to plasma membrane,
Golgi apparatus,
lysosome,
multivesicular body,
endoplasmic reticulum		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of ERK1 and ERK2 cascade,
protein complex assembly,
negative regulation of apoptosis,
positive thymic T cell selection,
prostaglandin biosynthetic process,
positive regulation of T cell differentiation,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
chaperone mediated protein folding requiring cofactor,
negative regulation of T cell differentiation,
intracellular protein transport,
antigen processing and presentation of exogenous peptide antigen via MHC class II,
negative thymic T cell selection,
defense response,
cell proliferation,
immunoglobulin mediated immune response,
positive regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 9   MDDQRDLISNHEQLPILGN - 19144319
HTP
1.00
 - MHC2-interact
0.52
 - medium

Substrate: CD74 (CD antigen)
Seq-ID: P04441-2 [Mus musculus]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
MHC class II protein binding,
cytokine receptor activity		 external side of plasma membrane,
integral to plasma membrane,
Golgi apparatus,
lysosome,
multivesicular body,
endoplasmic reticulum		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of ERK1 and ERK2 cascade,
protein complex assembly,
negative regulation of apoptosis,
positive thymic T cell selection,
prostaglandin biosynthetic process,
positive regulation of T cell differentiation,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
chaperone mediated protein folding requiring cofactor,
negative regulation of T cell differentiation,
intracellular protein transport,
antigen processing and presentation of exogenous peptide antigen via MHC class II,
negative thymic T cell selection,
defense response,
cell proliferation,
immunoglobulin mediated immune response,
positive regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 9   MDDQRDLISNHEQLPILGN - 19144319
HTP
1.00
 - MHC2-interact
0.52
 - medium

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