Substrate: CHK1 (Serine/threonine-protein kinase Chk1)
Seq-ID: O14757 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51394   CSK2B_HUMAN
MINT-1958329   P53_HUMAN
MINT-4793746   RB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 condensed nuclear chromosome,
microtubule organizing center,
nucleoplasm		 protein amino acid phosphorylation,
regulation of cyclin-dependent protein kinase activity,
senescence,
DNA repair,
reciprocal meiotic recombination,
negative regulation of cell proliferation,
DNA damage checkpoint,
gamete generation,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 280 KKGAKRPRVTSGGVSESPSGF PKB_group 12062056
LTP
0.04
 MOD_PKB_1
 - -
0.63
 2HOG 132.79%
S 280 KKGAKRPRVTSGGVSESPSGF - 18669648
HTP
0.04
 MOD_PKB_1
 - -
0.63
 2HOG 132.79%
S 284 KRPRVTSGGVSESPSGFSKHI - 18669648
HTP
0.04
 - -
0.58
 --
S 286 PRVTSGGVSESPSGFSKHIQS - 18669648
HTP
0.12
 - -
0.54
 --
S 296 SPSGFSKHIQSNLDFSPVNSA - 15975956
LTP
0.19
 - -
0.45
 --
S 296 SPSGFSKHIQSNLDFSPVNSA - 18669648
HTP
0.19
 - -
0.45
 --
S 301 SKHIQSNLDFSPVNSASSEEN CDK1 16629900
LTP
0.29
 - -
0.46
 --
S 301 SKHIQSNLDFSPVNSASSEEN - 18669648
HTP
0.29
 - -
0.46
 --
S 308 LDFSPVNSASSEENVKYSSSQ - 17525332
HTP
0.03
 - -
0.55
 --
S 317 SSEENVKYSSSQPEPRTGLSL ATM 11252893
LTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 317 SSEENVKYSSSQPEPRTGLSL ATR 11390642
LTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 317 SSEENVKYSSSQPEPRTGLSL - 17525332
HTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 317 SSEENVKYSSSQPEPRTGLSL - 18669648
HTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 331 PRTGLSLWDTSPSYIDKLVQG - 18669648
HTP
0.12
 - -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 11390642
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 10859164
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATM 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL - 15674326
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --

Substrate: CHK1 (Serine/threonine-protein kinase Chk1)
Seq-ID: O35280 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-58519   SMAD4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 replication fork,
microtubule organizing center,
nucleoplasm		 DNA repair,
G2/M transition of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 280 NRGAKRPRATSGGMSESSSGF - 15107605
LTP
0.18
 - -
0.70
 - medium
S 317 SSEETVKFSSSQPEPRTGLSL - 17525332
HTP
0.96
 - -
0.58
 - medium
S 345 VDKLVQGISFSQPTCPEHMLV - 16122425
LTP
1.00
 - -
0.39
 - medium

Valid HTML 4.01 Transitional