Substrate: CHK2 (Serine/threonine-protein kinase Chk2)
Seq-ID: O96017 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   P53_HUMAN
MINT-15591   MPIP1_HUMAN
MINT-49652   NBN_HUMAN
MINT-58599   MDM2_HUMAN
MINT-62311   IMA2_HUMAN
MINT-4793727   RB_HUMAN
MINT-6806274   STRAP_HUMAN
MINT-7294980   XRCC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 PML body protein amino acid phosphorylation,
senescence,
cell cycle,
DNA damage checkpoint,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 19 AQQSHGSSACSQPHGSVTQSQ ATM 10973490
LTP
0.75
 MOD_PIKK_1
 - -
0.81
 --
T 26 SACSQPHGSVTQSQGSSSQSQ ATM 10973490
LTP
0.82
 MOD_PIKK_1
 - -
0.79
 --
T 26 SACSQPHGSVTQSQGSSSQSQ PLK1 12493754
LTP
0.82
 MOD_PIKK_1
 - -
0.79
 --
S 28 CSQPHGSVTQSQGSSSQSQGI ATM 10973490
LTP
0.02
 MOD_PIKK_1
 - -
0.80
 --
S 33 GSVTQSQGSSSQSQGISSSST ATM 10973490
LTP
0.05
 MOD_PIKK_1
 - -
0.80
 --
S 35 VTQSQGSSSQSQGISSSSTST ATM 10973490
LTP
0.00
 MOD_PIKK_1
 - -
0.80
 --
S 50 SSSTSTMPNSSQSSHSSSGTL ATM 10973490
LTP
1.00
 MOD_PIKK_1
 - -
0.77
 --
T 68 GTLSSLETVSTQELYSIPEDQ ATM 10973490
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --
T 68 GTLSSLETVSTQELYSIPEDQ CHK2 11901158
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --
T 68 GTLSSLETVSTQELYSIPEDQ PLK1 12493754
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --
T 68 GTLSSLETVSTQELYSIPEDQ TTK 15618221
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --
T 383 KILGETSLMRTLCGTPTYLAP CHK2 11390408
LTP
1.00
 - S_TKc
0.13
 2W0J 40.41%
T 387 ETSLMRTLCGTPTYLAPEVLV CHK2 11390408
LTP
1.00
 - S_TKc
0.11
 2W0J 86.30%
S 456 NFIPEVWAEVSEKALDLVKKL - 17715138
LTP
1.00
 - S_TKc
0.10
 2W0J 32.79%
S 516 TALPQVLAQPSTSRKRPREGE CHK2 12805407
LTP
0.08
 - -
0.69
 --

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