Substrate: Caspase-3 (Cysteine protease CPP32)
Seq-ID: P42574 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13839   XIAP_HUMAN
MINT-18036   APAF_HUMAN
MINT-18815   CASP9_HUMAN
MINT-4820691   AKT1_HUMAN
MINT-4820707   AKT2_HUMAN
MINT-4820732   AKT3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cysteine-type endopeptidase activity,
protein binding		 plasma membrane,
mitochondrion,
cytosol,
nucleoplasm		 negative regulation of apoptosis,
proteolysis,
nuclear fragmentation involved in apoptotic nuclear change,
response to tumor necrosis factor
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 150 TNFFRGDRCRSLTGKPKLFII MAPK14 14970175
LTP
0.98
 - CASc
0.11
 2J32 20.49%

Substrate: Caspase-3 (Cysteine protease CPP32)
Seq-ID: P70677 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4050391   HD_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cysteine-type endopeptidase activity,
cyclin-dependent protein kinase inhibitor activity,
protein binding		 negative regulation of cyclin-dependent protein kinase activity,
negative regulation of activated T cell proliferation,
response to UV,
keratinocyte differentiation,
response to wounding,
release of cytochrome c from mitochondria,
cell fate commitment,
sensory perception of sound,
heart development,
B cell homeostasis,
induction of apoptosis via death domain receptors,
neuron apoptosis,
negative regulation of B cell proliferation,
T cell homeostasis,
induction of apoptosis by oxidative stress,
response to DNA damage stimulus,
DNA fragmentation involved in apoptotic nuclear change
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 26 FEVKTIHGSKSVDSGIYLDSS - 15345747
HTP
0.24
 - -
0.30
 - medium

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