Substrate: Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID: P49817 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7307575   TRXR1_HUMAN
MINT-7307618   TRXR1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
peptidase activator activity caveola,
integral to membrane of membrane fraction,
integral to plasma membrane,
perinuclear region of cytoplasm,
protein complex,
cell cortex,
endoplasmic reticulum,
Golgi membrane		 negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of vasoconstriction,
inactivation of MAPK activity,
negative regulation of tyrosine phosphorylation of Stat5 protein,
cholesterol homeostasis,
positive regulation of calcium ion transport into cytosol,
lipid storage,
mammary gland involution,
vasoconstriction,
negative regulation of nitric oxide biosynthetic process,
negative regulation of canonical Wnt receptor signaling pathway,
negative regulation of epithelial cell differentiation,
positive regulation of metalloenzyme activity,
response to calcium ion,
negative regulation of MAPKKK cascade,
lactation,
vasculogenesis,
calcium ion transport,
skeletal muscle tissue development,
T cell costimulation,
triglyceride metabolic process,
protein homooligomerization,
negative regulation of endothelial cell proliferation,
nitric oxide homeostasis,
endocytosis,
negative regulation of cytokine-mediated signaling pathway,
regulation of smooth muscle contraction,
membrane depolarization,
regulation of fatty acid metabolic process,
response to hypoxia,
response to estrogen stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 14 GKYVDSEGHLYTVPIREQGNI - 12036959
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI Abl 11075810
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 11075810
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 8632005
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI Abl 12531427
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI - 11094059
LTP
 - GRB7 SH2 Caveolin
0.30
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI - 15592455
HTP
 - GRB7 SH2 Caveolin
0.30
 - low

Substrate: Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID: Q03135 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14113   RASH_HUMAN
MINT-15459   SRC_HUMAN
MINT-50920   MDR1_HUMAN
MINT-6764866   PTN1_HUMAN
MINT-6793815   PTN6_HUMAN
MINT-6793823   PTEN_HUMAN
MINT-6793881   PTN11_HUMAN
MINT-7234712   SDPR_HUMAN
MINT-7234742   PRDBP_HUMAN
MINT-7307629   TRXR1_HUMAN
MINT-7309906   SCRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nitric-oxide synthase binding,
protein complex scaffold,
cholesterol binding,
peptidase activator activity,
receptor binding,
protein binding		 lipid particle,
basolateral plasma membrane,
caveola,
perinuclear region of cytoplasm,
apical plasma membrane,
endoplasmic reticulum,
Golgi membrane		 cellular response to starvation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of vasoconstriction,
inactivation of MAPK activity,
maintenance of protein location in cell,
regulation of blood coagulation,
negative regulation of BMP signaling pathway,
cholesterol homeostasis,
positive regulation of calcium ion transport into cytosol,
lipid storage,
mammary gland involution,
positive regulation of peptidyl-serine phosphorylation,
negative regulation of canonical Wnt receptor signaling pathway,
negative regulation of epithelial cell differentiation,
positive regulation of metalloenzyme activity,
negative regulation of peptidyl-serine phosphorylation,
calcium ion transport,
interspecies interaction between organisms,
cytosolic calcium ion homeostasis,
T cell costimulation,
triglyceride metabolic process,
protein homooligomerization,
vesicle organization,
negative regulation of endothelial cell proliferation,
nitric oxide homeostasis,
receptor internalization,
caveola assembly,
regulation of smooth muscle contraction,
membrane depolarization,
regulation of fatty acid metabolic process,
response to hypoxia,
response to estrogen stimulus,
positive regulation of canonical Wnt receptor signaling pathway,
response to progesterone stimulus,
negative regulation of nitric oxide biosynthetic process,
response to calcium ion,
negative regulation of MAPKKK cascade,
negative regulation of protein binding,
vasculogenesis,
skeletal muscle tissue development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 6      MSGGKYVDSEGHLYTV - 15951569
HTP
0.32
 - Caveolin
0.25
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI Fyn 12921535
LTP
0.69
 Csk SH2 Caveolin
0.29
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 12921535
LTP
0.69
 Csk SH2 Caveolin
0.29
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI - 14992595
LTP
0.69
 Csk SH2 Caveolin
0.29
 - low
Y 14 GKYVDSEGHLYTVPIREQGNI - 18083107
HTP
0.69
 Csk SH2 Caveolin
0.29
 - low
Y 25 TVPIREQGNIYKPNNKAMADE - 15951569
HTP
1.00
 - Caveolin
0.34
 - low
S 37 PNNKAMADELSEKQVYDAHTK - 15219854
LTP
0.32
 - Caveolin
0.31
 - low
S 37 PNNKAMADELSEKQVYDAHTK - 17081983
HTP
0.32
 - Caveolin
0.31
 - low
S 37 PNNKAMADELSEKQVYDAHTK - 18669648
HTP
0.32
 - Caveolin
0.31
 - low
S 80 DVIAEPEGTHSFDGIWKASFT - 11078729
LTP
1.00
 - Caveolin
0.11
 - low
S 88 THSFDGIWKASFTTFTVTKYW CK2_group 8058322
LTP
1.00
 - Caveolin
0.04
 - low
S 168 PLFEAVGKIFSNVRINLQKEI - 11078729
LTP
0.99
 - Caveolin
0.01
 - low

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