Phospho.ELM Result

a database of S/T/Y phosphorylation sites

ErbB2 (Receptor tyrosine kinase)

Seq-ID:

P04626 [Homo sapiens]

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Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

GO-Terms:

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Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding	receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm	regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	686	KRRQQKIRKYTMRRLLQETEL	-	8702975	LTP	1.00	-	-	0.29	-	low
T	686	KRRQQKIRKYTMRRLLQETEL	-	9855018	LTP	1.00	-	-	0.29	-	low
Y	735	VLGSGAFGTVYKGIWIPDGEN	-	18083107	HTP	1.00	-	TyrKc	0.09	-	low
Y	877	ARLLDIDETEYHADGGKVPIK	-	15695410	LTP	1.00	-	TyrKc	0.16	-	low
S	1054	HHRHRSSSTRSGGGDLTLGLE	-	18669648	HTP	0.30	-	-	0.77	-	low
Y	1112	PTHDPSPLQRYSEDPTVPLPS	-	10910043	LTP	1.00	-	-	0.92	-	low
S	1134	TDGYVAPLTCSPQPEYVNQPD	-	18669648	HTP	0.12	-	-	0.74	-	low
Y	1139	APLTCSPQPEYVNQPDVRPQP	ErbB2	11500516	LTP	1.00	GRB2 SH2; GRB7 SH2; Src SH2; STAT3 SH2	-	0.85	-	low
S	1151	NQPDVRPQPPSPREGPLPAAR	-	18669648	HTP	0.09	-	-	0.95	-	low
T	1172	PAGATLERPKTLSPGKNGVVK	CaM-KII_alpha	8700533	LTP	0.30	-	-	0.76	-	low
Y	1196	AFGGAVENPEYLTPQGGAAPQ	ErbB2	11500516	LTP	1.00	-	YLP	0.78	-	low
Y	1221	PAFSPAFDNLYYWDQDPPERG	ErbB2	11500516	LTP	0.19	GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.67	-	low
Y	1222	AFSPAFDNLYYWDQDPPERGA	ErbB2	11500516	LTP	1.00	SHC_group SH2; STAT3 SH2	-	0.68	-	low
Y	1248	KGTPTAENPEYLGLDVPV	ErbB2	11500516	LTP	1.00	MATK SH2	-	0.69	-	low
Y	1248	KGTPTAENPEYLGLDVPV	-	17081983	HTP	1.00	MATK SH2	-	0.69	-	low

ErbB2 (Receptor tyrosine kinase)

Seq-ID:

P70424 [Mus musculus]

Download:

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transmembrane receptor protein tyrosine kinase activity, DNA binding, receptor signaling protein tyrosine kinase activity, ATP binding	integral to membrane, nucleus, perinuclear region of cytoplasm, apical plasma membrane	neuromuscular junction development, transcription, negative regulation of immature T cell proliferation in the thymus, myelination, peripheral nervous system development, regulation of transcription, heart development, transmembrane receptor protein tyrosine kinase signaling pathway, motor axon guidance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	878	ARLLDIDETEYHADGGKVPIK	-	14647453	LTP	1.00		-	TyrKc	0.16	-	medium