Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61514   CSK_HUMAN
MINT-61518   GRB2_HUMAN
MINT-61520   P85B_HUMAN
MINT-74430   ABL1_HUMAN
MINT-74454   ABL2_HUMAN
MINT-74500   CRK_HUMAN
MINT-74505   CRKL_HUMAN
MINT-74509   DAB1_HUMAN
MINT-74510   DAPP1_HUMAN
MINT-74534   FER_HUMAN
MINT-74539   FGFR1_HUMAN
MINT-74548   GRB7_HUMAN
MINT-74550   HCK_HUMAN
MINT-74559   ITK_HUMAN
MINT-74563   JAK2_HUMAN
MINT-74564   JAK3_HUMAN
MINT-74569   SH2B3_HUMAN
MINT-74588   NCK1_HUMAN
MINT-74592   NCK2_HUMAN
MINT-74617   P85A_HUMAN
MINT-74672   P55G_HUMAN
MINT-74682   PLCG1_HUMAN
MINT-74688   PTK6_HUMAN
MINT-74708   RASA1_HUMAN
MINT-74714   RIN1_HUMAN
MINT-74738   SHC1_HUMAN
MINT-74753   SRC_HUMAN
MINT-74775   KSYK_HUMAN
MINT-74784   TENC1_HUMAN
MINT-74788   TENS3_HUMAN
MINT-74795   TXK_HUMAN
MINT-74803   VAV2_HUMAN
MINT-74806   ZAP70_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
transmembrane receptor protein tyrosine kinase activity,
receptor signaling protein tyrosine kinase activity,
protein homodimerization activity,
protein tyrosine kinase activator activity,
ATP binding,
growth factor binding		 receptor complex,
basolateral plasma membrane,
integral to plasma membrane,
extracellular space		 protein amino acid phosphorylation,
positive regulation of phosphoinositide 3-kinase cascade,
negative regulation of signal transduction,
phosphoinositide 3-kinase cascade,
heart development,
negative regulation of secretion,
neuron apoptosis,
negative regulation of neuron apoptosis,
regulation of cell proliferation,
negative regulation of cell adhesion,
transmembrane receptor protein tyrosine kinase signaling pathway,
cranial nerve development,
wound healing,
Schwann cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1199 EEEDEDEEYEYMNRRRRHSPP - 9516479
LTP
1.00
 GRB7 SH2;
PIK3R1 SH2		 -
0.92
 - medium
Y 1262 AGTTPDEDYEYMNRQRDGGGP - 9516479
LTP
0.07
 GRB7 SH2 -
0.88
 - medium
Y 1276 QRDGGGPGGDYAAMGACPASE - 11546794
LTP
0.31
 PIK3R1 SH2 -
0.76
 - medium
Y 1289 MGACPASEQGYEEMRAFQGPG - 11546794
LTP
0.12
 PIK3R1 SH2 -
0.67
 - medium
Y 1328 ATDSAFDNPDYWHSRLFPKAN - 9694850
LTP
1.00
 SHC1 PTB;
SHC_group SH2		 -
0.50
 - medium

Valid HTML 4.01 Transitional