Substrate: FAK (Focal adhesion kinase)
Seq-ID: P34152 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19677   FYN_MOUSE
MINT-49755   PAXI_MOUSE
MINT-4544473   GRB7_MOUSE
MINT-6762573   PTN1_HUMAN
MINT-6771387   L1CAM_MOUSE
MINT-6771405   SRC_HUMAN
MINT-7258938   PTN11_MOUSE
MINT-7303491   BCAR1_MOUSE
MINT-7303500   SRC_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
signal transducer activity		 focal adhesion,
cytosol,
lamellipodium,
cytoskeleton,
apical plasma membrane		 negative regulation of axonogenesis,
central nervous system neuron axonogenesis,
angiogenesis,
signal complex assembly,
negative regulation of organ growth,
integrin-mediated signaling pathway,
negative regulation of synaptogenesis,
extracellular matrix organization,
neuron migration,
protein amino acid autophosphorylation,
vasculogenesis,
endothelial cell migration,
establishment of nucleus localization,
microtubule cytoskeleton organization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 428 DEISGDETDDYAEIIDEEDTY - 14963034
LTP
1.00
 - -
0.60
 --
Y 428 DEISGDETDDYAEIIDEEDTY - 15890789
LTP
1.00
 - -
0.60
 --
Y 428 DEISGDETDDYAEIIDEEDTY - 15252114
LTP
1.00
 - -
0.60
 --
Y 428 DEISGDETDDYAEIIDEEDTY - 12637511
LTP
1.00
 - -
0.60
 --
Y 614 GLSRYMEDSTYYKASKGKLPI - 15592455
HTP
1.00
 - TyrKc
0.11
 --
Y 614 GLSRYMEDSTYYKASKGKLPI - 17242355
HTP
1.00
 - TyrKc
0.11
 --
Y 615 LSRYMEDSTYYKASKGKLPIK - 15592455
HTP
1.00
 - TyrKc
0.11
 --
Y 615 LSRYMEDSTYYKASKGKLPIK - 17242355
HTP
1.00
 - TyrKc
0.11
 --
S 948 EGVKLQPQEISPPPTANLDRS - 14963034
LTP
0.90
 - -
0.82
 1K04 77.87%
S 948 EGVKLQPQEISPPPTANLDRS - 17114649
HTP
0.90
 - -
0.82
 1K04 77.87%

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17602   LYN_HUMAN
MINT-74938   BCAR1_HUMAN
MINT-3381308   SRC_HUMAN
MINT-6794892   PTN1_HUMAN
MINT-7294020   P53_HUMAN
MINT-7385708   SRC_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
SH2 domain binding,
signal transducer activity		 focal adhesion,
cytosol,
cytoskeleton		 signal complex assembly,
integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 347 AENMADLIDGYCRLVNGTSQS - 12515828
LTP
1.00
 - -
0.21
 --
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
 Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2		 -
0.49
 --
Y 397 HAVSVSETDDYAEIIDEEDTY - 17192257
HTP
1.00
 Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2		 -
0.49
 --
Y 397 HAVSVSETDDYAEIIDEEDTY - 18083107
HTP
1.00
 Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2		 -
0.49
 --
Y 407 YAEIIDEEDTYTMPSTRDYEI - 7529876
LTP
1.00
 - -
0.50
 --
Y 407 YAEIIDEEDTYTMPSTRDYEI - 16254240
HTP
1.00
 - -
0.50
 --
Y 407 YAEIIDEEDTYTMPSTRDYEI - 15247219
LTP
1.00
 - -
0.50
 --
Y 407 YAEIIDEEDTYTMPSTRDYEI - 12960434
LTP
1.00
 - -
0.50
 --
Y 570 VKLGDFGLSRYMEDSTYYKAS - 18083107
HTP
1.00
 - TyrKc
0.09
 3BZ3 69.87%
Y 576 GLSRYMEDSTYYKASKGKLPI FAK 7529876
LTP
1.00
 - TyrKc
0.11
 2J0L 96.51%
Y 576 GLSRYMEDSTYYKASKGKLPI - 17192257
HTP
1.00
 - TyrKc
0.11
 2J0L 96.51%
Y 576 GLSRYMEDSTYYKASKGKLPI - 18083107
HTP
1.00
 - TyrKc
0.11
 2J0L 96.51%
Y 577 LSRYMEDSTYYKASKGKLPIK FAK 7529876
LTP
1.00
 - TyrKc
0.11
 2J0L 25.33%
Y 577 LSRYMEDSTYYKASKGKLPIK - 18083107
HTP
1.00
 - TyrKc
0.11
 2J0L 25.33%
S 722 PPKPSRPGYPSPRSSEGFYPS - 11160818
LTP
0.28
 - -
0.84
 --
S 722 PPKPSRPGYPSPRSSEGFYPS - 17192257
HTP
0.28
 - -
0.84
 --
S 732 SPRSSEGFYPSPQHMVQTNHY ROCK1 16760434
LTP
0.24
 - -
0.69
 --
S 840 ERFLKPDVRLSRGSIDREDGS - 11160818
LTP
1.00
 - -
0.65
 --
S 840 ERFLKPDVRLSRGSIDREDGS - 17081983
HTP
1.00
 - -
0.65
 --
S 840 ERFLKPDVRLSRGSIDREDGS - 17192257
HTP
1.00
 - -
0.65
 --
S 843 LKPDVRLSRGSIDREDGSLQG - 11160818
LTP
0.13
 - -
0.67
 --
S 843 LKPDVRLSRGSIDREDGSLQG - 17192257
HTP
0.13
 - -
0.67
 --
Y 861 LQGPIGNQHIYQPVGKPDPAA SRC 8941336
LTP
0.18
 - -
0.79
 --
Y 861 LQGPIGNQHIYQPVGKPDPAA SRC 11927607
LTP
0.18
 - -
0.79
 --
Y 861 LQGPIGNQHIYQPVGKPDPAA - 18083107
HTP
0.18
 - -
0.79
 --
S 892 PGHLGSLASLSSPADSYNEGV - 18669648
HTP
0.64
 - -
0.62
 --
S 910 EGVKLQPQEISPPPTANLDRS - 11160818
LTP
0.14
 - -
0.81
 1K04 77.87%
S 910 EGVKLQPQEISPPPTANLDRS - 17192257
HTP
0.14
 - -
0.81
 1K04 77.87%
S 910 EGVKLQPQEISPPPTANLDRS - 18669648
HTP
0.14
 - -
0.81
 1K04 77.87%
Y 925 ANLDRSNDKVYENVTGLVKAV - 12370821
LTP
1.00
 GRB2 SH2;
STAT3 SH2		 Focal_AT
0.45
 1K04 39.30%
Y 925 ANLDRSNDKVYENVTGLVKAV - 7997267
LTP
1.00
 GRB2 SH2;
STAT3 SH2		 Focal_AT
0.45
 1K04 39.30%

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