Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

GH-R (Growth hormon receptor)

Seq-ID:

P10912 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

[show]

MINT-6797534   DUS7_HUMAN
MINT-6797749   PTN2_HUMAN
MINT-6797775   PTN9_HUMAN
MINT-6797788   PTPRB_HUMAN
MINT-6797829   PTN1_HUMAN
MINT-6797890   PTN3_HUMAN
MINT-7250542   NCK1_HUMAN
MINT-7252318   P85A_HUMAN
MINT-7252594   PLCG1_HUMAN
MINT-7254526   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, protein kinase binding, peptide hormone binding, growth factor binding, proline-rich region binding	growth hormone receptor complex, integral to plasma membrane, cell surface, extracellular space	valine metabolic process, activation of JAK2 kinase activity, oxaloacetate metabolic process, creatinine metabolic process, isoleucine metabolic process, positive regulation of tyrosine phosphorylation of Stat3 protein, taurine metabolic process, positive regulation of tyrosine phosphorylation of Stat5 protein, response to estradiol stimulus, insulin-like growth factor receptor signaling pathway, allantoin metabolic process, fatty acid metabolic process, positive regulation of multicellular organism growth, response to cycloheximide, citrate metabolic process, activation of MAPK activity, multicellular organismal metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, growth hormone receptor signaling pathway, endocytosis, creatine metabolic process, receptor internalization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	332	VNTILAIHDSYKPEFHSDDSW	JAK2	9121492	LTP	0.90		-	-	0.23	-	low
Y	487	NPSSLSNIDFYAQVSDITPAG	JAK2	9121492	LTP	1.00		CISH SH2; GRB10 SH2; SOCS2 SH2; STAT3 SH2; STAT5 SH2	-	0.42	-	low
Y	534	CQENFLMDNAYFCEADAKKCI	-	9121492	LTP	0.93		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.16	-	low
Y	534	CQENFLMDNAYFCEADAKKCI	-	8647880	LTP	0.93		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.16	-	low
Y	566	IQPSLNQEDIYITTESLTTAA	-	9121492	LTP	1.00		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.47	-	low
Y	566	IQPSLNQEDIYITTESLTTAA	-	8647880	LTP	1.00		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.47	-	low
Y	627	PDKEFLSSCGYVSTDQLNKIM	-	9121492	LTP	1.00		STAT3 SH2; STAT5 SH2	-	0.29	-	low
Y	627	PDKEFLSSCGYVSTDQLNKIM	-	8647880	LTP	1.00		STAT3 SH2; STAT5 SH2	-	0.29	-	low