Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14688   SHC1_HUMAN
MINT-56633   MK03_HUMAN
MINT-68496   P85A_HUMAN
MINT-7220613   GRB2_HUMAN
MINT-7300434   1433B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 140 NVSSAGHGPRSSPAELSSSSQ - 18220336
HTP
0.21
 - -
0.67
 - low
S 159 SQHLLRERKSSAPSHSSQPTL PKB_group 11782427
LTP
0.66
 MOD_PKB_1
 - -
0.61
 - low
Y 266 RHNTEFRDSTYDLPRSLASHG - 12522270
HTP
0.08
 - -
0.66
 - low
Y 266 RHNTEFRDSTYDLPRSLASHG - 18083107
HTP
0.08
 - -
0.66
 - low
Y 293 TGSETDNEDVYTFKTPSNTLC - 11334882
LTP
0.30
 - -
0.61
 - low
Y 324 MDVPATPLSAYQIPRTFTLDK - 16497976
HTP
0.21
 - -
0.58
 - low
Y 452 RSDSTNSEDNYVPMNPGSSTL - 11334882
LTP
1.00
 - -
0.81
 - low
Y 476 ERAGDNSQSVYIPMSPGAHHF - 11334882
LTP
0.15
 - -
0.67
 - low
S 543 NTVIDELPFKSPITKSWSRAN - 18669648
HTP
0.92
 - -
0.53
 - low
Y 584 STDSGDSEENYVPMQNPVSAS - 11334882
LTP
0.93
 - -
0.85
 - low
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
 PTPN11 SH2;
SHC1 SH2		 -
0.69
 - low
S 623 DYLALDFQPSSPSPHRKPSTS MAPK3 15356145
LTP
0.90
 MOD_ProDKin_1
 - -
0.74
 - low
Y 643 SSVTSDEKVDYVQVDKEKTQA - 15170389
LTP
1.00
 PTPN11 SH2 -
0.71
 - low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
cell migration,
integrin-mediated signaling pathway,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 193 PTLSTSAPQEYLYLHQCISRR SRC_group 12819203
LTP
0.93
 SHC_group SH2 -
0.41
 - medium
S 402 MDNSRLHRASSCETYEYPARG - 17242355
HTP
0.17
 - -
0.66
 - medium
Y 441 RSNSASSDDNYVPMNPGSSTL - 9885561
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 441 RSNSASSDDNYVPMNPGSSTL - 11334882
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 9885561
LTP
0.15
 PIK3R1 SH2 -
0.78
 - medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 11334882
LTP
0.15
 PIK3R1 SH2 -
0.78
 - medium
Y 573 STDSGDSEENYVPMQNPVSAS - 9885561
LTP
0.93
 PIK3R1 SH2 -
0.85
 - medium
Y 573 STDSGDSEENYVPMQNPVSAS - 11334882
LTP
0.93
 PIK3R1 SH2 -
0.85
 - medium
Y 603 APKKSTGSVDYLALDFQPGSP SRC_group 9885561
LTP
0.96
 PTPN11 SH2 -
0.70
 - medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 9885561
LTP
1.00
 PTPN11 SH2 -
0.71
 - medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 11640929
LTP
1.00
 PTPN11 SH2 -
0.71
 - medium

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