Substrate: HDAC5 (histone deacetylase activity, specific transcriptional repressor activity)
Seq-ID: Q9UQL6 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-65796   EF1G_HUMAN
MINT-3318337   1433Z_HUMAN
MINT-6802102   HIF1A_HUMAN
MINT-7299978   BUB1B_HUMAN
MINT-7710106   PKN2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
transcription repressor binding,
specific transcriptional repressor activity,
histone deacetylase activity,
transcription factor binding		 histone deacetylase complex,
cytoplasm		 B cell differentiation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of myotube differentiation,
transcription,
histone deacetylation,
positive regulation of transcription factor activity,
chromatin silencing,
inflammatory response,
negative regulation of cell migration involved in sprouting angiogenesis,
chromatin remodeling,
cellular response to insulin stimulus,
regulation of protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 259 RDDFPLRKTASEPNLKVRSRL CaM-KIV 11081517
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.69
 - medium
S 498 PRHRPLSRTQSSPLPQSPQAL CaM-KIV 11081517
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.88
 - medium

Substrate: HDAC5 (histone deacetylase activity, specific transcriptional repressor activity)
Seq-ID: Q9Z2V6 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-19666   MEF2D_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
specific transcriptional repressor activity,
histone deacetylase activity,
transcription corepressor activity		 histone deacetylase complex,
nuclear body,
cytosol		 B cell differentiation,
nervous system development,
chromatin modification,
transcription,
response to cocaine,
negative regulation of striated muscle tissue development,
osteoblast development,
negative regulation of osteoblast differentiation,
inflammatory response,
heart development,
regulation of skeletal muscle fiber development,
negative regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 250 RDDFPLRKTASEPNLKVRSRL - 11114197
LTP
1.00
 - -
0.68
 - low
S 488 PRHRPLSRTQSSPLPQSPQAL - 11114197
LTP
1.00
 - -
0.87
 - low

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