Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-47837   REL_HUMAN
MINT-47839   IKBB_HUMAN
MINT-47840   ELP1_HUMAN
MINT-47841   IKKA_HUMAN
MINT-47842   IKKB_HUMAN
MINT-47843   NEMO_HUMAN
MINT-47845   MCM7_HUMAN
MINT-48656   NFKB1_HUMAN
MINT-48721   NFKB2_HUMAN
MINT-48993   RELB_HUMAN
MINT-64895   MED19_HUMAN
MINT-6762163   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nuclear localization sequence binding,
identical protein binding,
ubiquitin protein ligase binding,
NF-kappaB binding		 cytosol,
I-kappaB/NF-kappaB complex,
nucleus		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
cytoplasmic sequestering of NF-kappaB,
negative regulation of NF-kappaB transcription factor activity,
apoptosis,
anti-apoptosis,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
positive regulation of cholesterol efflux,
interspecies interaction between organisms,
positive regulation of cellular protein metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 32 KERLLDDRHDSGLDSMKDEEY CK2_group 10398585
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY IKK_group 10723127
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 9214631
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 12403772
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 12138192
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 8657102
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 16007147
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY - 7796813
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY IKK_group 10882136
LTP
1.00
 - -
0.63
 --
S 36 LDDRHDSGLDSMKDEEYEQMV CK2_group 10398585
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV - 12403772
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV - 12138192
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV - 8657102
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV - 16007147
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV - 7796813
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV IKK_group 10882136
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV IKK_group 9346484
LTP
1.00
 - -
0.65
 --
Y 42 SGLDSMKDEEYEQMVKELQEI Lck 8797825
LTP
1.00
 PIK3R1 SH2 -
0.55
 --
Y 42 SGLDSMKDEEYEQMVKELQEI - 12432072
LTP
1.00
 PIK3R1 SH2 -
0.55
 --
Y 42 SGLDSMKDEEYEQMVKELQEI SRC 9792645
LTP
1.00
 PIK3R1 SH2 -
0.55
 --
S 283 TLENLQMLPESEDEESYDTES CK2_group 8622692
LTP
1.00
 MOD_CK2_1
 - -
0.65
 1IKN 91.80%
S 283 TLENLQMLPESEDEESYDTES CK2_alpha 8622692
LTP
1.00
 MOD_CK2_1
 - -
0.65
 1IKN 91.80%
S 288 QMLPESEDEESYDTESEFTEF CK2_alpha 8622692
LTP
1.00
 MOD_CK2_1
 - -
0.70
 1IKN 17.21%
T 291 PESEDEESYDTESEFTEFTED CK2_group 8622692
LTP
0.00
 MOD_CK2_1
 - -
0.73
 1IKN 45.89%
T 291 PESEDEESYDTESEFTEFTED CK2_alpha 8622692
LTP
0.00
 MOD_CK2_1
 - -
0.73
 1IKN 45.89%
S 293 SEDEESYDTESEFTEFTEDEL CK2_alpha 12167702
LTP
0.79
 MOD_CK2_1
 - -
0.73
 1IKN 0.0%
Y 305 FTEFTEDELPYDDCVFGGQRL Abl 14757045
LTP
0.16
 - -
0.34
 --

Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: Q9Z1E3 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-19530   TF65_MOUSE
MINT-50016   TF65_HUMAN
MINT-50067   KAPCA_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol,
nucleus		 negative regulation of myeloid cell differentiation,
negative regulation of Notch signaling pathway,
lipopolysaccharide-mediated signaling pathway,
response to exogenous dsRNA,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
regulation of cell proliferation,
nucleotide-binding oligomerization domain containing 1 signaling pathway,
protein import into nucleus, translocation,
response to muramyl dipeptide,
toll-like receptor 4 signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 32 KERLVDDRHDSGLDSMKDEEY IKK_epsilon 10421793
LTP
1.00
 - -
0.65
 - medium
S 36 VDDRHDSGLDSMKDEEYEQMV IKK_epsilon 10421793
LTP
1.00
 - -
0.65
 - medium
S 293 SEDEESYDTESEFTEDELPYD CK2_alpha 8668171
LTP
0.07
 MOD_CK2_1
 - -
0.72
 - medium

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