Substrate: ITCH (protein binding, ubiquitin-protein ligase activity)
Seq-ID: Q8C863 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7040747   RBP1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding,
ubiquitin-protein ligase activity		 plasma membrane,
membrane fraction,
cytoplasmic vesicle,
nucleus,
cell cortex		 positive regulation of protein catabolic process,
negative regulation of apoptosis,
apoptosis,
positive regulation of T cell anergy,
negative regulation of alpha-beta T cell proliferation,
negative regulation of defense response to virus,
innate immune response,
protein K48-linked ubiquitination,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
protein K63-linked ubiquitination,
protein K29-linked ubiquitination,
protein polyubiquitination,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 199 GENKRANGNNSPSLSNGGFKP MAPK8 16446428
LTP
0.40
 MOD_ProDKin_1
 - -
0.88
 - medium
T 222 PPRPSRPPPPTPRRPASVNGS MAPK8 16446428
LTP
0.50
 MOD_ProDKin_1
 - -
0.98
 - medium
S 232 TPRRPASVNGSPSTNSDSDGS MAPK8 16446428
LTP
0.39
 MOD_ProDKin_1
 - -
0.96
 - medium

Substrate: ITCH (protein binding, ubiquitin-protein ligase activity)
Seq-ID: Q96J02 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19902   SH3G2_HUMAN
MINT-50139   CASL_HUMAN
MINT-58329   CBLC_HUMAN
MINT-58331   CBL_HUMAN
MINT-2881316   SGK3_HUMAN
MINT-3389173   P73_HUMAN
MINT-4050151   TRPV4_MOUSE
MINT-7542986   BID_MOUSE
MINT-7889719   SNX18_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ribonucleoprotein binding,
CXCR chemokine receptor binding,
ubiquitin-protein ligase activity		 plasma membrane,
nucleus		 regulation of cell growth,
negative regulation of apoptosis,
apoptosis,
negative regulation of defense response to virus,
inflammatory response,
innate immune response,
protein K48-linked ubiquitination,
protein K63-linked ubiquitination,
entry of virus into host cell,
protein K29-linked ubiquitination,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 420 AMQQFNQRFIYGNQDLFATSQ Fyn 16387660
LTP
0.96
 - -
0.39
 - low

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