Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: O60674 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   BRCA1_HUMAN
MINT-61281   G3BP1_HUMAN
MINT-74562   EGFR_HUMAN
MINT-74563   ERBB3_HUMAN
MINT-6764602   PTN1_HUMAN
MINT-7250518   NCK1_HUMAN
MINT-7251766   P85A_HUMAN
MINT-7252666   PLCG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding,
SH2 domain binding		 cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
cytokine-mediated signaling pathway,
cellular component movement,
mesoderm development,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway,
response to antibiotic
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 570 FKGVRREVGDYGQLHETEVLL - 16464493
LTP
0.20
 - STYKc
0.19
 --
Y 813 RDLNSLFTPDYELLTENDMLP - 15767667
LTP
0.95
 SH2B1 SH2 -
0.28
 --
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 SOCS1 SH2;
SOCS3 SH2		 TyrKc
0.27
 3E62 61.14%
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 11818507
LTP
1.00
 - TyrKc
0.25
 3E62 40.17%

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: Q62120 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17285   PTPRC_MOUSE
MINT-2738306   SHC1_HUMAN
MINT-3378545   EPOR_MOUSE
MINT-4507367   KPCA_HUMAN
MINT-6795050   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
interleukin-12 receptor binding,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 caveola,
cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
positive regulation of phosphoinositide 3-kinase cascade,
STAT protein nuclear translocation,
cytokine-mediated signaling pathway,
negative regulation of cell proliferation,
apoptosis,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of growth hormone receptor signaling pathway,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
negative regulation of DNA binding,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143187
LTP
0.57
 - B41
0.08
 - medium
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143188
LTP
0.57
 - B41
0.08
 - medium
S 523 RTNGISDVQISPTLQRHNNVN - 16705160
LTP
0.25
 - -
0.37
 - medium
S 523 RTNGISDVQISPTLQRHNNVN - 16705159
LTP
0.25
 - -
0.37
 - medium
S 523 RTNGISDVQISPTLQRHNNVN - 19144319
HTP
0.25
 - -
0.37
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143187
LTP
0.20
 - STYKc
0.16
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 16705159
LTP
0.20
 - STYKc
0.16
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143188
LTP
0.20
 - STYKc
0.16
 - medium
Y 813 RDLNSLFTPDYELLTENDMLP JAK2 15121872
LTP
0.95
 - -
0.28
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP Abl 11593427
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15143187
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP - 16705160
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP - 16705159
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP - 15923602
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP - 15793561
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15530433
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 9111318
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI Abl 11593427
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI - 16705160
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI - 16705159
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI - 15923602
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI - 15793561
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 15530433
LTP
1.00
 - TyrKc
0.25
 - medium

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