Substrate: NPM (nucleophosmin (nucleolar phosphoprotein B23) (from PhosphoBase))
Seq-ID: P06748 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48882   M3K14_HUMAN
MINT-74886   P53_HUMAN
MINT-75016   PTBP1_HUMAN
MINT-75017   SFRS1_HUMAN
MINT-3089429   E2AK2_HUMAN
MINT-3296152   1433Z_HUMAN
MINT-4544864   AP2A_HUMAN
MINT-4544899   HDAC1_HUMAN
MINT-4544944   HDAC2_HUMAN
MINT-6541788   SENP3_HUMAN
MINT-7041169   HABP4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Tat protein binding,
histone binding,
ribosomal small subunit binding,
protein heterodimerization activity,
ribosomal large subunit binding,
protein homodimerization activity,
unfolded protein binding,
transcription coactivator activity,
NF-kappaB binding		 spindle pole centrosome response to stress,
negative regulation of cell proliferation,
negative regulation of centrosome duplication,
nucleosome assembly,
anti-apoptosis,
cell aging,
signal transduction,
protein oligomerization,
intracellular protein transport,
centrosome cycle,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
ribosome assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 4        MEDSMDMDMSPLRP PLK1 15190079
LTP
1.00
 MOD_PLK
 - -
0.63
 --
S 4        MEDSMDMDMSPLRP - 17081983
HTP
1.00
 MOD_PLK
 - -
0.63
 --
S 10  MEDSMDMDMSPLRPQNYLFG - 17081983
HTP
1.00
 - -
0.41
 --
Y 67 LHIVEAEAMNYEGSPIKVTLA - 18669648
HTP
0.96
 - Nucleoplasmin
0.40
 --
S 70 VEAEAMNYEGSPIKVTLATLK - 16565220
HTP
0.92
 - Nucleoplasmin
0.40
 --
S 70 VEAEAMNYEGSPIKVTLATLK - 17081983
HTP
0.92
 - Nucleoplasmin
0.40
 --
S 70 VEAEAMNYEGSPIKVTLATLK - 17287340
HTP
0.92
 - Nucleoplasmin
0.40
 --
S 70 VEAEAMNYEGSPIKVTLATLK - 18220336
HTP
0.92
 - Nucleoplasmin
0.40
 --
S 70 VEAEAMNYEGSPIKVTLATLK - 18669648
HTP
0.92
 - Nucleoplasmin
0.40
 --
T 75 MNYEGSPIKVTLATLKMSVQP - 18669648
HTP
1.00
 - Nucleoplasmin
0.45
 --
T 78 EGSPIKVTLATLKMSVQPTVS - 18669648
HTP
1.00
 - Nucleoplasmin
0.45
 --
S 88 TLKMSVQPTVSLGGFEITPPV - 18220336
HTP
0.95
 - Nucleoplasmin
0.48
 --
T 95 PTVSLGGFEITPPVVLRLKCG - 16041368
LTP
0.98
 - Nucleoplasmin
0.41
 --
T 95 PTVSLGGFEITPPVVLRLKCG - 18220336
HTP
0.98
 - Nucleoplasmin
0.41
 --
T 95 PTVSLGGFEITPPVVLRLKCG - 18669648
HTP
0.98
 - Nucleoplasmin
0.41
 --
S 125 HLVAVEEDAESEDEEEEDVKL - 3944116
LTP
1.00
 - Nucleoplasmin
0.78
 --
S 125 HLVAVEEDAESEDEEEEDVKL - 17081983
HTP
1.00
 - Nucleoplasmin
0.78
 --
S 125 HLVAVEEDAESEDEEEEDVKL - 17287340
HTP
1.00
 - Nucleoplasmin
0.78
 --
S 125 HLVAVEEDAESEDEEEEDVKL - 18220336
HTP
1.00
 - Nucleoplasmin
0.78
 --
S 125 HLVAVEEDAESEDEEEEDVKL - 18669648
HTP
1.00
 - Nucleoplasmin
0.78
 --
S 137 DEEEEDVKLLSISGKRSAPGG - 17287340
HTP
0.61
 - Nucleoplasmin
0.78
 --
S 137 DEEEEDVKLLSISGKRSAPGG - 18669648
HTP
0.61
 - Nucleoplasmin
0.78
 --
S 139 EEEDVKLLSISGKRSAPGGGS - 18669648
HTP
0.98
 - Nucleoplasmin
0.75
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ - 7213797
LTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ - 16083285
HTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ CDK1 12058066
LTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ CDK1 15190079
LTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ - 17081983
HTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 199 KAPVKKSIRDTPAKNAQKSNQ - 17287340
HTP
1.00
 MOD_CDK_SPxK_1
 - Nucleoplasmin
0.83
 --
T 219 QNGKDSKPSSTPRSKGQESFK - 12058066
LTP
0.48
 - -
0.89
 --
S 227 SSTPRSKGQESFKKQEKTPKT PKC_group 1446684
LTP
1.00
 - -
0.89
 --
T 234 GQESFKKQEKTPKTPKGPSSV CDK1 14670079
LTP
0.97
 - -
0.86
 --
T 234 GQESFKKQEKTPKTPKGPSSV - 17287340
HTP
0.97
 - -
0.86
 --
T 234 GQESFKKQEKTPKTPKGPSSV - 18669648
HTP
0.97
 - -
0.86
 --
T 237 SFKKQEKTPKTPKGPSSVEDI CDK1 14670079
LTP
1.00
 - -
0.85
 --
T 237 SFKKQEKTPKTPKGPSSVEDI - 17287340
HTP
1.00
 - -
0.85
 --
T 237 SFKKQEKTPKTPKGPSSVEDI - 18669648
HTP
1.00
 - -
0.85
 --
S 243 KTPKTPKGPSSVEDIKAKMQA - 18669648
HTP
1.00
 - -
0.85
 --
S 254 VEDIKAKMQASIEKGGSLPKV - 16565220
HTP
1.00
 - -
0.71
 --
S 254 VEDIKAKMQASIEKGGSLPKV - 17081983
HTP
1.00
 - -
0.71
 --
S 254 VEDIKAKMQASIEKGGSLPKV - 18669648
HTP
1.00
 - -
0.71
 --
S 260 KMQASIEKGGSLPKVEAKFIN - 17287340
HTP
0.97
 - -
0.58
 --
S 260 KMQASIEKGGSLPKVEAKFIN - 18669648
HTP
0.97
 - -
0.58
 --
T 279 INYVKNCFRMTDQEAIQDLWQ - 18220336
HTP
0.97
 - -
0.40
 --
T 279 INYVKNCFRMTDQEAIQDLWQ - 18669648
HTP
0.97
 - -
0.40
 --

Substrate: NPM (nucleophosmin (nucleolar phosphoprotein B23) (from PhosphoBase))
Seq-ID: P06748-2 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Tat protein binding,
histone binding,
ribosomal small subunit binding,
protein heterodimerization activity,
ribosomal large subunit binding,
protein homodimerization activity,
unfolded protein binding,
transcription coactivator activity,
NF-kappaB binding		 spindle pole centrosome response to stress,
negative regulation of cell proliferation,
negative regulation of centrosome duplication,
nucleosome assembly,
anti-apoptosis,
cell aging,
signal transduction,
protein oligomerization,
intracellular protein transport,
centrosome cycle,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
ribosome assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 67 LHIVEAEAMNYEGSPIKVTLA - 18669648
HTP
0.99
 - Nucleoplasmin
0.40
 - medium
S 70 VEAEAMNYEGSPIKVTLATLK - 18220336
HTP
1.00
 - Nucleoplasmin
0.40
 - medium
S 70 VEAEAMNYEGSPIKVTLATLK - 18669648
HTP
1.00
 - Nucleoplasmin
0.40
 - medium
T 75 MNYEGSPIKVTLATLKMSVQP - 18669648
HTP
1.00
 - Nucleoplasmin
0.45
 - medium
T 78 EGSPIKVTLATLKMSVQPTVS - 18669648
HTP
1.00
 - Nucleoplasmin
0.45
 - medium
S 88 TLKMSVQPTVSLGGFEITPPV - 18220336
HTP
0.99
 - Nucleoplasmin
0.48
 - medium
T 95 PTVSLGGFEITPPVVLRLKCG - 18220336
HTP
1.00
 - Nucleoplasmin
0.41
 - medium
T 95 PTVSLGGFEITPPVVLRLKCG - 18669648
HTP
1.00
 - Nucleoplasmin
0.41
 - medium
S 125 HLVAVEEDAESEDEEEEDVKL - 18220336
HTP
1.00
 - Nucleoplasmin
0.77
 - medium
S 125 HLVAVEEDAESEDEEEEDVKL - 18669648
HTP
1.00
 - Nucleoplasmin
0.77
 - medium
S 137 DEEEEDVKLLSISGKRSAPGG - 18669648
HTP
0.12
 - Nucleoplasmin
0.74
 - medium
S 139 EEEDVKLLSISGKRSAPGGGS - 18669648
HTP
1.00
 - Nucleoplasmin
0.70
 - medium

Substrate: NPM (nucleophosmin (nucleolar phosphoprotein B23) (from PhosphoBase))
Seq-ID: ENSMUSP00000075067 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
rRNA binding,
protein binding		 centrosome,
granular component,
cytosol,
large ribosomal subunit,
small ribosomal subunit,
nuclear speck		 ribosomal large subunit biogenesis,
positive regulation of cell proliferation,
positive regulation of protein kinase activity,
cell volume homeostasis,
ribosomal small subunit biogenesis,
cell growth,
positive regulation of cellular biosynthetic process,
positive regulation of centrosome duplication,
regulation of DNA damage response, signal transduction by p53 class mediator,
rRNA export from nucleus,
ribosomal small subunit export from nucleus,
negative regulation of nuclear mRNA splicing, via spliceosome,
ribosomal large subunit export from nucleus,
protein localization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 VEAEAMNYEGSPIKVTLATLK - 19144319
HTP
 - - Nucleoplasmin
0.42
 - medium
S 125 HLVAVEEDAESEDEDEEDVKL - 19144319
HTP
 - - Nucleoplasmin
0.79
 - medium

Substrate: NPM (nucleophosmin (nucleolar phosphoprotein B23) (from PhosphoBase))
Seq-ID: Q61937 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-68675   RS27_MOUSE
MINT-68676   YBOX1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
rRNA binding,
DNA binding,
unfolded protein binding,
NF-kappaB binding		 granular component,
cytosol,
large ribosomal subunit,
small ribosomal subunit,
nuclear speck		 ribosomal large subunit biogenesis,
positive regulation of cell proliferation,
positive regulation of protein kinase activity,
cell volume homeostasis,
ribosomal small subunit biogenesis,
negative regulation of cell proliferation,
cell growth,
positive regulation of centrosome duplication,
cell aging,
regulation of DNA damage response, signal transduction by p53 class mediator,
centrosome cycle,
rRNA export from nucleus,
ribosomal small subunit export from nucleus,
negative regulation of nuclear mRNA splicing, via spliceosome,
ribosomal large subunit export from nucleus,
protein localization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 VEAEAMNYEGSPIKVTLATLK - 19144319
HTP
0.92
 - Nucleoplasmin
0.42
 --
S 125 HLVAVEEDAESEDEDEEDVKL - 16452087
HTP
1.00
 - Nucleoplasmin
0.79
 --
S 258 KMQASIEKGGSLPKVEAKFIN - 17203969
HTP
0.96
 - -
0.57
 --

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