Substrate: Neurofibromin (GTPase activating protein)
Seq-ID: P21359 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3380416   SUMO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Ras GTPase activator activity,
protein binding		 cytoplasm,
nucleus,
axon,
dendrite		 positive regulation of Ras GTPase activity,
actin cytoskeleton organization,
positive regulation of neuron apoptosis,
collagen fibril organization,
MAPKKK cascade,
negative regulation of transcription factor import into nucleus,
smooth muscle tissue development,
osteoblast differentiation,
phosphoinositide 3-kinase cascade,
spinal cord development,
regulation of blood vessel endothelial cell migration,
heart development,
metanephros development,
camera-type eye morphogenesis,
negative regulation of MAPKKK cascade,
visual learning,
adrenal gland development,
liver development,
negative regulation of cell migration,
positive regulation of adenylate cyclase activity,
forebrain morphogenesis,
myelination in the peripheral nervous system,
Ras protein signal transduction,
negative regulation of oligodendrocyte differentiation,
wound healing,
negative regulation of neuroblast proliferation,
artery morphogenesis,
negative regulation of endothelial cell proliferation,
cerebral cortex development,
pigmentation,
forebrain astrocyte development,
regulation of angiogenesis,
regulation of bone resorption,
regulation of cell-matrix adhesion,
sympathetic nervous system development,
negative regulation of MAP kinase activity,
response to hypoxia
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 864 QRSNSGLATYSPPMGPVSERK - 15302935
HTP
1.00
 - -
0.60
 - medium
S 864 QRSNSGLATYSPPMGPVSERK - 18669648
HTP
1.00
 - -
0.60
 - medium
S 2188 FRSSYRDRSFSPGSYERETFA - 16565220
HTP
1.00
 - -
0.16
 - medium
S 2188 FRSSYRDRSFSPGSYERETFA - 18669648
HTP
1.00
 - -
0.16
 - medium
Y 2476 ISMENVPMDTYPIHHGDPSYR - 18083107
HTP
1.00
 - -
0.52
 - medium
S 2495 YRTLKETQPWSSPKGSEGYLA - 18669648
HTP
0.75
 - -
0.54
 - medium
S 2496 RTLKETQPWSSPKGSEGYLAA - 18669648
HTP
1.00
 - -
0.53
 - medium
T 2514 LAATYPTVGQTSPRARKSMSL - 18669648
HTP
0.41
 - -
0.60
 - medium
S 2515 AATYPTVGQTSPRARKSMSLD - 15302935
HTP
1.00
 - -
0.63
 - medium
S 2515 AATYPTVGQTSPRARKSMSLD - 18220336
HTP
1.00
 - -
0.63
 - medium
S 2515 AATYPTVGQTSPRARKSMSLD - 18669648
HTP
1.00
 - -
0.63
 - medium
S 2521 VGQTSPRARKSMSLDMGQPSQ - 18669648
HTP
1.00
 - -
0.80
 - medium
S 2523 QTSPRARKSMSLDMGQPSQAN - 18669648
HTP
1.00
 - -
0.81
 - medium
S 2543 NTKKLLGTRKSFDHLISDTKA - 18669648
HTP
1.00
 - -
0.49
 - medium
S 2829 SQVQKQRSAGSFKRNSIKKIV - 16083285
HTP
1.00
 - -
0.51
 - medium

Substrate: Neurofibromin (GTPase activating protein)
Seq-ID: Q04690 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activator activity,
protein binding		 cytoplasm,
nucleus		 positive regulation of endothelial cell proliferation,
positive regulation of Ras GTPase activity,
actin cytoskeleton organization,
negative regulation of angiogenesis,
positive regulation of neuron apoptosis,
collagen fibril organization,
MAPKKK cascade,
negative regulation of astrocyte differentiation,
negative regulation of transcription factor import into nucleus,
smooth muscle tissue development,
osteoblast differentiation,
spinal cord development,
heart development,
metanephros development,
camera-type eye morphogenesis,
negative regulation of MAPKKK cascade,
visual learning,
negative regulation of cell-matrix adhesion,
skeletal muscle tissue development,
adrenal gland development,
liver development,
negative regulation of cell migration,
positive regulation of adenylate cyclase activity,
forebrain morphogenesis,
myelination in the peripheral nervous system,
negative regulation of neurotransmitter secretion,
Ras protein signal transduction,
negative regulation of oligodendrocyte differentiation,
negative regulation of osteoclast differentiation,
wound healing,
negative regulation of neuroblast proliferation,
negative regulation of Rac protein signal transduction,
neural tube development,
regulation of long-term neuronal synaptic plasticity,
artery morphogenesis,
negative regulation of endothelial cell proliferation,
cerebral cortex development,
pigmentation,
forebrain astrocyte development,
regulation of bone resorption,
sympathetic nervous system development,
negative regulation of MAP kinase activity,
regulation of synaptic transmission, GABAergic,
response to hypoxia,
phosphoinositide 3-kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 2516 LAATYPAVGQTSPRARKSMSL - 17114649
HTP
0.41
 - -
0.58
 - medium

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