Substrate: Nibrin (NIBRIN (NIJMEGEN BREAKAGE syndrome protein 1) (Cell cycle regulatory protein P95).)
Seq-ID: O60934 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49652   CHK2_HUMAN
MINT-6805510   MDC1_HUMAN
MINT-7231018   RAD50_HUMAN
MINT-7906687   FACD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription factor binding,
protein N-terminus binding		 nucleolus,
Golgi apparatus,
nucleoplasm,
nuclear inclusion body,
Mre11 complex,
nuclear chromosome, telomeric region		 mitotic cell cycle G1/S transition checkpoint,
DNA damage response, signal transduction by p53 class mediator,
positive regulation of kinase activity,
cell cycle arrest,
DNA duplex unwinding,
telomere maintenance,
positive regulation of protein amino acid autophosphorylation,
mitotic cell cycle G2/M transition DNA damage checkpoint,
double-strand break repair,
meiosis,
regulation of DNA-dependent DNA replication initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 278 TCVVDTGITNSQTLIPDCQKK ATM 10839544
LTP
0.93
 MOD_PIKK_1
 - -
0.37
 - high
S 278 TCVVDTGITNSQTLIPDCQKK ATM 15279770
LTP
0.93
 MOD_PIKK_1
 - -
0.37
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM - 11252893
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 10839545
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 10839544
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM - 15302935
HTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 15279770
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM - 17525332
HTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM - 18669648
HTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 397 SKMEQKFRMLSQDAPTVKESC - 11252893
LTP
0.14
 MOD_PIKK_1
 - -
0.59
 - high
S 397 SKMEQKFRMLSQDAPTVKESC ATM 10839545
LTP
0.14
 MOD_PIKK_1
 - -
0.59
 - high
S 397 SKMEQKFRMLSQDAPTVKESC - 17525332
HTP
0.14
 MOD_PIKK_1
 - -
0.59
 - high
S 397 SKMEQKFRMLSQDAPTVKESC - 18669648
HTP
0.14
 MOD_PIKK_1
 - -
0.59
 - high
S 432 AKMRIPNYQLSPTKLPSINKS - 16964243
HTP
0.11
 - -
0.66
 - high
S 432 AKMRIPNYQLSPTKLPSINKS - 18669648
HTP
0.11
 - -
0.66
 - high
T 434 MRIPNYQLSPTKLPSINKSKD - 18669648
HTP
0.00
 - -
0.69
 - high
S 615 DEAVPESSKISQENEIGKKRE - 18669648
HTP
0.70
 - -
0.65
 - high

Substrate: Nibrin (NIBRIN (NIJMEGEN BREAKAGE syndrome protein 1) (Cell cycle regulatory protein P95).)
Seq-ID: Q9R207 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
damaged DNA binding,
transcription factor binding,
protein N-terminus binding		 replication fork,
nuclear inclusion body,
Mre11 complex		 mitotic cell cycle G1/S transition checkpoint,
isotype switching,
blastocyst growth,
telomere maintenance,
mitotic cell cycle G2/M transition DNA damage checkpoint,
regulation of fibroblast proliferation,
double-strand break repair,
neuromuscular process controlling balance,
meiosis,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 398 PGLEQSSRKLSQETFNIKEAP - 17525332
HTP
0.97
 - -
0.65
 - medium

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