Substrate: PARK2 (protein binding, ubiquitin-protein ligase activity)
Seq-ID: O60260 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-5208697   UBS3B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
kinase binding,
chaperone binding,
zinc ion binding,
PDZ domain binding,
ubiquitin-protein ligase activity		 cytosol,
Golgi apparatus,
aggresome,
nucleus,
perinuclear region of cytoplasm,
endoplasmic reticulum		 central nervous system development,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
aggresome assembly,
protein autoubiquitination,
negative regulation of cell death,
negative regulation of actin filament bundle assembly,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
protein K63-linked ubiquitination,
negative regulation of release of cytochrome c from mitochondria,
protein polyubiquitination,
regulation of oxygen and reactive oxygen species metabolic process,
cell death,
negative regulation of protein amino acid phosphorylation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 101 AAGGCEREPQSLTRVDLSSSV CK1_alpha 15557340
LTP
1.00
 - -
0.49
 --
S 131 VILHTDSRKDSPPAGSPAGRS - 15557340
LTP
0.92
 - -
0.65
 --
S 136 DSRKDSPPAGSPAGRSIYNSF - 15557340
LTP
0.03
 - -
0.55
 --
S 296 SLPCVAGCPNSLIKELHHFRI - 15557340
LTP
1.00
 - -
0.03
 --
S 378 CKEAYHEGECSAVFEASGTTT CK1_alpha 15557340
LTP
0.67
 - -
0.17
 --

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