Substrate: PTEN (Lipid phosphatase)
Seq-ID: O08586 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2832839   NHRF1_HUMAN
MINT-2832929   NHRF2_MOUSE
MINT-2832945   NHRF2_HUMAN
MINT-2833145   PGFRB_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity,
protein tyrosine phosphatase activity,
phosphatidylinositol-3-phosphatase activity,
protein serine/threonine phosphatase activity,
protein tyrosine/serine/threonine phosphatase activity,
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity,
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity,
PDZ domain binding		 nucleus inositol phosphate dephosphorylation,
cardiac muscle tissue development,
central nervous system development,
negative regulation of apoptosis,
regulation of cell cycle,
angiogenesis,
regulation of myeloid cell apoptosis,
negative regulation of epithelial cell proliferation,
regulation of neuron projection development,
apoptosis,
protein amino acid dephosphorylation,
prostate gland growth,
phosphoinositide dephosphorylation,
negative regulation of cell migration,
induction of apoptosis,
endothelial cell migration,
regulation of B cell apoptosis,
regulation of protein stability,
negative regulation of focal adhesion assembly,
negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 370 SSSTSVTPDVSDNEPDHYRYS - 17242355
HTP
0.79
 - -
0.76
 - low
S 380 SDNEPDHYRYSDTTDSDPENE - 14522959
LTP
1.00
 - -
0.87
 - low
S 385 DHYRYSDTTDSDPENEPFDED - 17242355
HTP
1.00
 - -
0.86
 - low

Substrate: PTEN (Lipid phosphatase)
Seq-ID: P60484 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity,
protein tyrosine phosphatase activity,
phosphatidylinositol-3-phosphatase activity,
lipid binding,
protein serine/threonine phosphatase activity,
protein tyrosine/serine/threonine phosphatase activity,
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity,
enzyme binding,
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity,
PDZ domain binding		 cytosol,
nucleus		 protein stabilization,
inositol phosphate dephosphorylation,
central nervous system development,
regulation of cyclin-dependent protein kinase activity,
regulation of neuron projection development,
apoptosis,
positive regulation of transcription factor activity,
protein amino acid dephosphorylation,
canonical Wnt receptor signaling pathway,
phosphoinositide dephosphorylation,
negative regulation of cell migration,
induction of apoptosis,
negative regulation of focal adhesion assembly,
negative regulation of protein kinase B signaling cascade,
cell proliferation,
negative regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 229 QLKVKIYSSNSGPTRREDKFM ROCK1 15793569
LTP
0.58
 - PTEN_C2
0.21
 1D5R 41.80%
T 232 VKIYSSNSGPTRREDKFMYFE ROCK1 15793569
LTP
0.05
 - PTEN_C2
0.21
 1D5R 50.00%
Y 240 GPTRREDKFMYFEFPQPLPVC Lck 11948419
LTP
0.46
 - PTEN_C2
0.22
 1D5R 10.48%
Y 315 SIERADNDKEYLVLTLTKNDL Lck 11948419
LTP
0.11
 - PTEN_C2
0.38
 1D5R 27.95%
S 362 EEPSNPEASSSTSVTPDVSDN GSK-3_beta 16107342
LTP
0.79
 MOD_GSK3_1
 - -
0.87
 --
T 366 NPEASSSTSVTPDVSDNEPDH - 12297295
LTP
0.79
 MOD_GSK3_1
 - -
0.83
 --
T 366 NPEASSSTSVTPDVSDNEPDH GSK-3_beta 16107342
LTP
0.79
 MOD_GSK3_1
 - -
0.83
 --
S 370 SSSTSVTPDVSDNEPDHYRYS - 12297295
LTP
0.79
 MOD_CK2_1
 - -
0.76
 --
S 370 SSSTSVTPDVSDNEPDHYRYS CK2_alpha 16107342
LTP
0.79
 MOD_CK2_1
 - -
0.76
 --
S 370 SSSTSVTPDVSDNEPDHYRYS CK2_alpha 11035045
LTP
0.79
 MOD_CK2_1
 - -
0.76
 --
S 380 SDNEPDHYRYSDTTDSDPENE - 12077256
LTP
1.00
 - -
0.87
 --
S 380 SDNEPDHYRYSDTTDSDPENE - 10866658
LTP
1.00
 - -
0.87
 --
S 380 SDNEPDHYRYSDTTDSDPENE CK2_alpha 11035045
LTP
1.00
 - -
0.87
 --
T 382 NEPDHYRYSDTTDSDPENEPF - 10866658
LTP
1.00
 MOD_CK2_1
 - -
0.87
 --
T 382 NEPDHYRYSDTTDSDPENEPF CK2_alpha 11035045
LTP
1.00
 MOD_CK2_1
 - -
0.87
 --
T 382 NEPDHYRYSDTTDSDPENEPF LKB1 18321849
LTP
1.00
 MOD_CK2_1
 - -
0.87
 --
T 383 EPDHYRYSDTTDSDPENEPFD - 10866658
LTP
1.00
 - -
0.87
 --
S 385 DHYRYSDTTDSDPENEPFDED CK2_group 12297295
LTP
1.00
 MOD_CK2_1
 - -
0.86
 --
S 385 DHYRYSDTTDSDPENEPFDED - 12077256
LTP
1.00
 MOD_CK2_1
 - -
0.86
 --
S 385 DHYRYSDTTDSDPENEPFDED CK2_group 16107342
LTP
1.00
 MOD_CK2_1
 - -
0.86
 --
S 385 DHYRYSDTTDSDPENEPFDED CK2_alpha 11035045
LTP
1.00
 MOD_CK2_1
 - -
0.86
 --

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