Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
S 130 QDGEDDGDYESPNEEEEAPVE - 15714472
LTP
0.15
 - -
0.98
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA TXK 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA ZAP70 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium
Y 173 AKPFPNSNSMYIDRPPSGKTP - 16094384
HTP
1.00
 - -
0.91
 - medium
S 207 LPPPPAGRNHSPLPPPQTNHE - 15144186
HTP
0.07
 - -
0.99
 - medium
S 207 LPPPPAGRNHSPLPPPQTNHE - 16094384
HTP
0.07
 - -
0.99
 - medium
S 207 LPPPPAGRNHSPLPPPQTNHE - 15714472
LTP
0.07
 - -
0.99
 - medium
S 207 LPPPPAGRNHSPLPPPQTNHE - 18088087
HTP
0.07
 - -
0.99
 - medium
S 376 ESNSSFPQSASLPPYFSQGPS MAP4K1 17353368
LTP
0.17
 YWHAE 14-3-3 -
0.74
 - medium
S 410 LPLPNKPRPPSPAEEENSLNE - 15714472
LTP
0.10
 - -
0.83
 - medium

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q60787 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol mast cell activation,
cytokine secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 112 DGGWSSFEDDYESPNDDDPDG - 12640123
LTP
0.00
 - -
0.89
 - medium
Y 128 DDPDGEDDGDYESPNEEEQAL - 12640123
LTP
1.00
 - -
0.97
 - medium
Y 145 EQALVDDAADYEPPPSNNEEA - 12640123
LTP
1.00
 - -
0.93
 - medium
S 210 LPTGRNHSPLSPPHPNHEEPS - 19144319
HTP
0.84
 - -
0.98
 - medium

Valid HTML 4.01 Transitional