Substrate: SMAD3 (Transcription regulatory protein)
Seq-ID: P84022 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14023   CEBPB_HUMAN
MINT-15105   MED15_HUMAN
MINT-19375   LAP2_MOUSE
MINT-51235   SRBP2_HUMAN
MINT-51239   41_HUMAN
MINT-51243   MYO5B_HUMAN
MINT-51244   TPM3_HUMAN
MINT-51245   CRK_HUMAN
MINT-51247   GT2D1_HUMAN
MINT-51248   LMNA_HUMAN
MINT-51249   VIME_HUMAN
MINT-51250   SF3A1_HUMAN
MINT-51251   ACTB_HUMAN
MINT-51253   PYGL_HUMAN
MINT-61695   MLL4_HUMAN
MINT-61696   KU70_HUMAN
MINT-61697   KDM2A_HUMAN
MINT-61703   GMEB1_HUMAN
MINT-61705   PCDH1_HUMAN
MINT-61707   ZEB2_HUMAN
MINT-61710   RANB9_HUMAN
MINT-61711   MCM3A_HUMAN
MINT-61716   MTF2_HUMAN
MINT-61717   CFDP1_HUMAN
MINT-61720   SP130_HUMAN
MINT-61721   NCOA6_HUMAN
MINT-61723   K1267_HUMAN
MINT-61726   ZEP1_HUMAN
MINT-61732   GI24_HUMAN
MINT-61733   FLNA_HUMAN
MINT-61734   RLA0_HUMAN
MINT-61735   RU17_HUMAN
MINT-61737   TGM2_HUMAN
MINT-61949   SMAD4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transforming growth factor beta receptor binding,
protein homodimerization activity,
R-SMAD binding,
protein kinase binding,
co-SMAD binding,
ubiquitin protein ligase binding,
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity,
beta-catenin binding,
transcription factor binding,
promoter binding,
sequence-specific DNA binding transcription factor activity		 nuclear inner membrane,
receptor complex,
cytosol		 protein stabilization,
negative regulation of cell growth,
SMAD protein complex assembly,
cell cycle arrest,
positive regulation of canonical Wnt receptor signaling pathway,
positive regulation of catenin protein nuclear translocation,
activation of caspase activity,
immune response,
regulation of transforming growth factor beta receptor signaling pathway,
transport,
positive regulation of transcription factor import into nucleus,
regulation of transforming growth factor-beta2 production,
transforming growth factor beta receptor signaling pathway,
negative regulation of mitotic cell cycle,
wound healing,
induction of apoptosis,
positive regulation of epithelial to mesenchymal transition,
cell-cell junction organization,
negative regulation of protein amino acid phosphorylation,
primary microRNA processing,
transcription,
evasion of host defenses by virus,
negative regulation of protein catabolic process,
response to hypoxia
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 8    MSSILPFTPPIVKRLLGW - 15241418
LTP
1.00
 - -
0.17
 1OZJ 32.19%
T 8    MSSILPFTPPIVKRLLGW CDK2 15520018
LTP
1.00
 - -
0.17
 1OZJ 32.19%
T 8    MSSILPFTPPIVKRLLGW CDK4 15520018
LTP
1.00
 - -
0.17
 1OZJ 32.19%
T 179 GIEPQSNIPETPPPGYLSEDG CDK2 15241418
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
T 179 GIEPQSNIPETPPPGYLSEDG CDK4 15241418
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
T 179 GIEPQSNIPETPPPGYLSEDG - 15520018
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
T 179 GIEPQSNIPETPPPGYLSEDG MAPK1 10197981
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
T 179 GIEPQSNIPETPPPGYLSEDG MAPK1 16156666
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
S 204 HQMNHSMDAGSPNLSPNPMSP MAPK1 15241418
LTP
0.77
 MOD_ProDKin_1
 - -
0.81
 --
S 204 HQMNHSMDAGSPNLSPNPMSP - 15520018
LTP
0.77
 MOD_ProDKin_1
 - -
0.81
 --
S 204 HQMNHSMDAGSPNLSPNPMSP MAPK1 10197981
LTP
0.77
 MOD_ProDKin_1
 - -
0.81
 --
S 204 HQMNHSMDAGSPNLSPNPMSP MAPK1 16156666
LTP
0.77
 MOD_ProDKin_1
 - -
0.81
 --
S 208 HSMDAGSPNLSPNPMSPAHNN MAPK1 15241418
LTP
0.47
 MOD_ProDKin_1
 - -
0.77
 --
S 208 HSMDAGSPNLSPNPMSPAHNN - 15520018
LTP
0.47
 MOD_ProDKin_1
 - -
0.77
 --
S 208 HSMDAGSPNLSPNPMSPAHNN MAPK1 10197981
LTP
0.47
 MOD_ProDKin_1
 - -
0.77
 --
S 208 HSMDAGSPNLSPNPMSPAHNN MAPK1 16156666
LTP
0.47
 MOD_ProDKin_1
 - -
0.77
 --
S 213 GSPNLSPNPMSPAHNNLDLQP CDK2 15241418
LTP
0.82
 MOD_ProDKin_1
 - -
0.68
 --
S 213 GSPNLSPNPMSPAHNNLDLQP CDK4 15241418
LTP
0.82
 MOD_ProDKin_1
 - -
0.68
 --
S 213 GSPNLSPNPMSPAHNNLDLQP - 15520018
LTP
0.82
 MOD_ProDKin_1
 - -
0.68
 --
S 213 GSPNLSPNPMSPAHNNLDLQP MAPK1 10197981
LTP
0.82
 MOD_ProDKin_1
 - -
0.68
 --
S 416 WLDKVLTQMGSPSIRCSSVS  - 18669648
HTP
0.91
 - -
0.18
 1MJS 81.97%
S 422 TQMGSPSIRCSSVS        - 9380693
LTP
0.98
 - -
0.25
 1U7F 43.44%
S 423 QMGSPSIRCSSVS         - 9380693
LTP
0.09
 - -
0.22
 1U7F 182.79%
S 425 GSPSIRCSSVS           - 9380693
LTP
0.00
 - -
0.16
 1U7F 151.64%

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