Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-63063   PIN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase inhibitor activity regulation of growth,
negative regulation of signal transduction,
anti-apoptosis,
JAK-STAT cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 204 RKTVNGHLDSYEKVTQLPGPI Lck 12783885
LTP
0.19
 - SOCS_box
0.51
 --
Y 221 PGPIREFLDQYDAPL       - 12783885
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O35718 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2576222   LEPR_MOUSE
MINT-3382101   IL6RB_MOUSE
MINT-6797017   MAP1S_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding placenta blood vessel development,
negative regulation of insulin receptor signaling pathway,
positive regulation of cell differentiation,
spongiotrophoblast differentiation,
regulation of growth,
negative regulation of signal transduction,
trophoblast giant cell differentiation,
regulation of protein amino acid phosphorylation,
branching involved in embryonic placenta morphogenesis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 204 RKTVNGHLDSYEKVTQLPGPI - 11325969
LTP
0.17
 - SOCS_box
0.48
 --

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