Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

SOS1 (Guanine nucleotide exchange factor)

Seq-ID:

Q07889 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

[show]

MINT-16551   ABI1_HUMAN
MINT-16777   ITSN1_HUMAN
MINT-1782423   SHC1_HUMAN
MINT-3389635   RASH_HUMAN
MINT-6170118   GRB2_HUMAN
MINT-7051548   HCK_HUMAN
MINT-7135462   EPS8_HUMAN
MINT-7230708   SPD2A_HUMAN
MINT-7245622   SRC_HUMAN
MINT-7247530   FYN_HUMAN
MINT-7250662   NCK1_HUMAN
MINT-7251526   P85A_HUMAN
MINT-7252678   PLCG1_HUMAN
MINT-7254274   CRK_HUMAN
MINT-7971296   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, DNA binding, Rho GTPase activator activity, protein binding	cytosol	induction of apoptosis by extracellular signals, apoptosis, Ras protein signal transduction, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1043	YPLKSPGVRPSNPRPGTMRHP	-	12509440	LTP	0.48		-	-	0.85	2II0	57.38%
S	1082	ETESTASAPNSPRTPLTPPPA	-	15302935	HTP	0.52		-	-	0.94	-	-
S	1132	IQVTLPHGPRSASVSSISLTK	MAPK1	8816480	LTP	0.26		-	-	0.71	-	-
S	1134	VTLPHGPRSASVSSISLTKGT	-	18669648	HTP	0.57		-	-	0.78	-	-
S	1137	PHGPRSASVSSISLTKGTDEV	-	18669648	HTP	0.68		-	-	0.83	-	-
S	1167	RRPESAPAESSPSKIMSKHLD	MAPK1	8816480	LTP	0.50	MOD_ProDKin_1	-	-	0.90	-	-
S	1178	PSKIMSKHLDSPPAIPPRQPT	MAPK1	8816480	LTP	0.21	MOD_ProDKin_1	-	-	0.88	-	-
S	1193	PPRQPTSKAYSPRYSISDRTS	MAPK1	8816480	LTP	0.28	MOD_ProDKin_1	-	-	0.79	-	-
S	1197	PTSKAYSPRYSISDRTSISDP	MAPK1	8816480	LTP	0.31		-	-	0.78	-	-
S	1210	DRTSISDPPESPPLLPPREPV	-	15302935	HTP	0.40		-	-	0.92	-	-

SOS1 (Guanine nucleotide exchange factor)

Seq-ID:

Q62245 [Mus musculus]

Download:

Interaction Network(s):

-

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-3382457   LAT_HUMAN
MINT-5226862   SHC1_MOUSE
MINT-6169976   GRB2_HUMAN
MINT-6170031   EGFR_HUMAN
MINT-7302595   ITSN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, DNA binding, protein binding	intracellular	regulation of Rho protein signal transduction, small GTPase mediated signal transduction, fibroblast growth factor receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1078	IPESETESTASAPNSPRTPLT	-	17242355	HTP	0.40		-	-	0.92	-	medium
S	1082	ETESTASAPNSPRTPLTPPPA	-	17242355	HTP	0.52		-	-	0.94	-	medium
S	1082	ETESTASAPNSPRTPLTPPPA	-	17114649	HTP	0.52		-	-	0.94	-	medium