Substrate: Sequestosome-1 (Adapter protein which binds ubiquitin)
Seq-ID: Q13501 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-64602   TOE1_HUMAN
MINT-66276   GBRL2_HUMAN
MINT-66845   RD23A_HUMAN
MINT-2844278   MALT1_HUMAN
MINT-2844414   NEMO_HUMAN
MINT-7264745   BAG3_HUMAN
MINT-7717318   MK03_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
receptor tyrosine kinase binding,
ubiquitin binding,
zinc ion binding,
SH2 domain binding		 late endosome,
cytosol,
nucleoplasm		 intracellular signaling pathway,
induction of apoptosis by extracellular signals,
regulation of I-kappaB kinase/NF-kappaB cascade,
apoptosis,
anti-apoptosis,
endosome transport,
macroautophagy,
cell differentiation,
positive regulation of transcription from RNA polymerase II promoter,
chaperone-mediated autophagy,
protein localization,
ubiquitin-dependent protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 28 REIRRFSFCCSPEPEAEAEAA - 18669648
HTP
1.00
 - PB1
0.32
 - low
Y 148 TRYKCSVCPDYDLCSVCEGKG - 15592455
HTP
1.00
 - ZnF_ZZ
0.08
 - low
S 170 HRGHTKLAFPSPFGHLSEGFS - 18669648
HTP
0.53
 - -
0.41
 - low
S 182 FGHLSEGFSHSRWLRKVKHGH - 18669648
HTP
1.00
 - -
0.37
 - low
S 207 GWEMGPPGNWSPRPPRAGEAR - 18669648
HTP
0.84
 - -
0.84
 - low
S 266 DIDVEHGGKRSRLTPVSPESS - 17081983
HTP
1.00
 - -
0.82
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 16083285
HTP
1.00
 - -
0.87
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 16565220
HTP
1.00
 - -
0.87
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 17081983
HTP
1.00
 - -
0.87
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 16964243
HTP
1.00
 - -
0.87
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 17287340
HTP
1.00
 - -
0.87
 - low
T 269 VEHGGKRSRLTPVSPESSSTE - 18669648
HTP
1.00
 - -
0.87
 - low
S 272 GGKRSRLTPVSPESSSTEEKS - 16083285
HTP
0.97
 - -
0.89
 - low
S 272 GGKRSRLTPVSPESSSTEEKS - 16565220
HTP
0.97
 - -
0.89
 - low
S 272 GGKRSRLTPVSPESSSTEEKS - 17081983
HTP
0.97
 - -
0.89
 - low
S 272 GGKRSRLTPVSPESSSTEEKS - 16964243
HTP
0.97
 - -
0.89
 - low
S 272 GGKRSRLTPVSPESSSTEEKS - 18669648
HTP
0.97
 - -
0.89
 - low
S 275 RSRLTPVSPESSSTEEKSSSQ - 18669648
HTP
0.89
 - -
0.90
 - low
S 276 SRLTPVSPESSSTEEKSSSQP - 18669648
HTP
1.00
 - -
0.89
 - low
S 277 RLTPVSPESSSTEEKSSSQPS - 18669648
HTP
1.00
 - -
0.88
 - low
T 278 LTPVSPESSSTEEKSSSQPSS - 17081983
HTP
1.00
 - -
0.88
 - low
T 278 LTPVSPESSSTEEKSSSQPSS - 18669648
HTP
1.00
 - -
0.88
 - low
S 282 SPESSSTEEKSSSQPSSCCSD - 18669648
HTP
0.92
 - -
0.86
 - low
S 284 ESSSTEEKSSSQPSSCCSDPS - 18669648
HTP
0.93
 - -
0.88
 - low
S 287 STEEKSSSQPSSCCSDPSKPG - 18669648
HTP
1.00
 - -
0.88
 - low
S 288 TEEKSSSQPSSCCSDPSKPGG - 18669648
HTP
1.00
 - -
0.88
 - low
S 291 KSSSQPSSCCSDPSKPGGNVE - 18669648
HTP
1.00
 - -
0.87
 - low
S 328 SEGRPEEQMESDNCSGGDDDW - 17081983
HTP
1.00
 - -
0.90
 - low
S 328 SEGRPEEQMESDNCSGGDDDW - 18669648
HTP
1.00
 - -
0.90
 - low
S 332 PEEQMESDNCSGGDDDWTHLS - 17081983
HTP
1.00
 - -
0.84
 - low
S 332 PEEQMESDNCSGGDDDWTHLS - 18669648
HTP
1.00
 - -
0.84
 - low
S 343 GGDDDWTHLSSKEVDPSTGEL - 18669648
HTP
1.00
 - -
0.80
 - low
S 355 EVDPSTGELQSLQMPESEGPS - 18669648
HTP
1.00
 - -
0.92
 - low
S 361 GELQSLQMPESEGPSSLDPSQ - 17287340
HTP
1.00
 - -
0.94
 - low
S 361 GELQSLQMPESEGPSSLDPSQ - 18669648
HTP
1.00
 - -
0.94
 - low
S 365 SLQMPESEGPSSLDPSQEGPT - 17287340
HTP
0.79
 - -
0.95
 - low
S 365 SLQMPESEGPSSLDPSQEGPT - 18669648
HTP
0.79
 - -
0.95
 - low
S 366 LQMPESEGPSSLDPSQEGPTG - 17287340
HTP
1.00
 - -
0.95
 - low
S 366 LQMPESEGPSSLDPSQEGPTG - 18669648
HTP
1.00
 - -
0.95
 - low

Substrate: Sequestosome-1 (Adapter protein which binds ubiquitin)
Seq-ID: Q64337 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
ubiquitin binding,
zinc ion binding,
transcription cofactor activity,
SH2 domain binding		 late endosome,
nucleus		 regulation of I-kappaB kinase/NF-kappaB cascade,
apoptosis,
macroautophagy,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 24 EEATREIRRFSFCFSPEPEAE - 17242355
HTP
1.00
 - PB1
0.35
 - medium
T 271 HGGKRSRLTPTTPESSSTGTE - 19144319
HTP
0.80
 - -
0.92
 - medium
T 272 GGKRSRLTPTTPESSSTGTED - 19144319
HTP
0.00
 - -
0.93
 - medium
S 334 PEEQMESGNCSGGDDDWTHLS - 19144319
HTP
1.00
 - -
0.84
 - medium
S 357 EVDPSTGELQSLQMPESEGPS - 19144319
HTP
1.00
 - -
0.93
 - medium
S 363 GELQSLQMPESEGPSSLDPSQ - 19144319
HTP
0.69
 - -
0.95
 - medium

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