Substrate: Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID: P22893 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
AU-rich element binding,
mRNA binding,
zinc ion binding		 cytosol,
nucleus		 negative regulation of myeloid cell differentiation,
negative regulation of inflammatory response,
nuclear-transcribed mRNA poly(A) tail shortening,
regulation of mRNA stability,
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening,
RNA destabilization,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 52 VTSRLTGRSTSLVEGRSCGWV MAPKAPK2 14688255
LTP
1.00
 YWHAB 14-3-3 -
0.45
 - low
S 80 PLAPRPGPELSPSPTSPTATP MAPKAPK2 14688255
LTP
0.62
 MOD_ProDKin_1
 - -
0.86
 - low
S 82 APRPGPELSPSPTSPTATPTT MAPKAPK2 14688255
LTP
0.62
 MOD_ProDKin_1
 - -
0.89
 - low
S 85 PGPELSPSPTSPTATPTTSSR MAPKAPK2 14688255
LTP
0.51
 MOD_ProDKin_1
 - -
0.87
 - low
S 178 GQPHVLRQSISFSGLPSGRRS MAPKAPK2 14688255
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.65
 - low
S 220 SPPPPGDLPLSPSAFSAAPGT MAPK_group 7768935
LTP
0.66
 MOD_ProDKin_1
 - -
0.77
 - low
T 250 ACCPSCRRSTTPSTIWGPLGG MAPKAPK2 14688255
LTP
0.33
 MOD_ProDKin_1
 - -
0.43
 - low
S 316 PRRLPIFNRISVSE        MAPKAPK2 14688255
LTP
1.00
 - -
0.48
 - low

Substrate: Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID: P26651 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
AU-rich element binding,
mRNA binding,
single-stranded RNA binding,
zinc ion binding,
protein binding		 cytosol,
nucleus		 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 66 GRSTSLVEGRSCGWVPPPPGF - 16262601
LTP
0.90
 - -
0.48
 - low
S 88 PLAPRLGPELSPSPTSPTATS - 16262601
LTP
0.30
 - -
0.78
 - low
T 92 RLGPELSPSPTSPTATSTTPS - 16262601
LTP
0.07
 - -
0.83
 - low
S 169 GSRCHFIHNPSEDLAAPGHPP - 16262601
LTP
0.21
 - -
0.46
 - low
S 186 GHPPVLRQSISFSGLPSGRRT - 18669648
HTP
1.00
 YWHAB 14-3-3 -
0.66
 - low
S 197 FSGLPSGRRTSPPPPGLAGPS - 16262601
LTP
0.24
 - -
0.77
 - low
S 218 LSSSSFSPSSSPPPPGDLPLS - 16262601
LTP
0.95
 - -
0.74
 - low
S 228 SPPPPGDLPLSPSAFSAAPGT - 16262601
LTP
0.91
 - -
0.73
 - low
S 276 GGLVRTPSVQSLGSDPDEYAS - 16262601
LTP
0.10
 - -
0.70
 - low
S 296 SSGSSLGGSDSPVFEAGVFAP - 16262601
LTP
1.00
 - -
0.56
 - low

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