Substrate: Tuberin (GTPase activating protein)
Seq-ID: P49815 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14051   1433T_HUMAN
MINT-16238   TSC1_HUMAN
MINT-16580   1433F_HUMAN
MINT-17162   1433B_HUMAN
MINT-17710   1433S_HUMAN
MINT-3317863   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
GTPase activator activity		 TSC1-TSC2 complex,
Golgi apparatus,
nucleus,
perinuclear region of cytoplasm		 neural tube closure,
protein import into nucleus,
regulation of insulin receptor signaling pathway,
positive regulation of GTPase activity,
insulin-like growth factor receptor signaling pathway,
heart development,
negative regulation of phosphoinositide 3-kinase cascade,
superior temporal gyrus development,
positive chemotaxis,
protein kinase B signaling cascade,
regulation of small GTPase mediated signal transduction,
regulation of endocytosis,
endocytosis,
negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 540 IIEKVMARSLSPPPELEERDV - 15851026
LTP
0.05
 - -
0.30
 - medium
S 664 GSEKKTSGPLSPPTGPPGPAP MAPK1 15851026
LTP
1.00
 MOD_ProDKin_1
 - Tuberin
0.88
 - medium
T 927 RSNVLLSFDDTPEKDSFRARS - 18669648
HTP
0.09
 - -
0.30
 - medium
S 939 EKDSFRARSTSLNERPKSLRI - 12438239
LTP
1.00
 MOD_PKB_1
 - -
0.48
 - medium
S 939 EKDSFRARSTSLNERPKSLRI PKB_group 12150915
LTP
1.00
 MOD_PKB_1
 - -
0.48
 - medium
S 939 EKDSFRARSTSLNERPKSLRI PKB_group 15342917
LTP
1.00
 MOD_PKB_1
 - -
0.48
 - medium
S 981 AAEAFRCRSISVSEHVVRSRI - 15342917
LTP
1.00
 - -
0.22
 - medium
S 981 AAEAFRCRSISVSEHVVRSRI - 18669648
HTP
1.00
 - -
0.22
 - medium
S 1096 GELQSGPESSSSPGVHVRQTK - 18669648
HTP
0.08
 - -
0.82
 - medium
S 1097 ELQSGPESSSSPGVHVRQTKE - 18220336
HTP
0.84
 - -
0.84
 - medium
S 1097 ELQSGPESSSSPGVHVRQTKE - 18669648
HTP
0.84
 - -
0.84
 - medium
S 1132 RGARDRVRSMSGGHGLRVGAL - 18669648
HTP
1.00
 - -
0.58
 - medium
S 1155 PASQFLGSATSPGPRTAPAAK - 18220336
HTP
0.30
 - -
0.75
 - medium
S 1155 PASQFLGSATSPGPRTAPAAK - 18669648
HTP
0.30
 - -
0.75
 - medium
S 1254 HRDTALYKSLSVPAASTAKPP MAPKAPK2 12582162
LTP
0.11
 - -
0.56
 - medium
S 1334 LGMDRRTDAYSRSSSVSSQEE - 18669648
HTP
0.86
 - -
0.71
 - medium
S 1337 DRRTDAYSRSSSVSSQEEKSL - 18669648
HTP
0.89
 - -
0.73
 - medium
S 1338 RRTDAYSRSSSVSSQEEKSLH - 18669648
HTP
0.98
 - -
0.72
 - medium
S 1341 DAYSRSSSVSSQEEKSLHAEE - 18669648
HTP
0.89
 - -
0.67
 - medium
S 1385 SFQPSQPLSKSSSSPELQTLQ - 18669648
HTP
1.00
 - -
0.79
 - medium
S 1386 FQPSQPLSKSSSSPELQTLQD - 18669648
HTP
1.00
 - -
0.79
 - medium
S 1387 QPSQPLSKSSSSPELQTLQDI - 15963462
LTP
1.00
 - -
0.80
 - medium
S 1387 QPSQPLSKSSSSPELQTLQDI - 18669648
HTP
1.00
 - -
0.80
 - medium
S 1388 PSQPLSKSSSSPELQTLQDIL - 18669648
HTP
1.00
 - -
0.81
 - medium
T 1393 SKSSSSPELQTLQDILGDPGD - 18669648
HTP
1.00
 - -
0.83
 - medium
S 1411 PGDKADVGRLSPEVKARSQSG - 17081983
HTP
0.09
 - -
0.79
 - medium
S 1411 PGDKADVGRLSPEVKARSQSG - 18669648
HTP
0.09
 - -
0.79
 - medium
S 1418 GRLSPEVKARSQSGTLDGESA - 15963462
LTP
0.03
 - -
0.71
 - medium
S 1420 LSPEVKARSQSGTLDGESAAW - 15963462
LTP
0.05
 - -
0.69
 - medium
S 1420 LSPEVKARSQSGTLDGESAAW - 18669648
HTP
0.05
 - -
0.69
 - medium
S 1448 RGQPEGPLPSSSPRSPSGLRP - 18669648
HTP
0.03
 - -
0.93
 - medium
S 1449 GQPEGPLPSSSPRSPSGLRPR - 18669648
HTP
0.25
 - -
0.91
 - medium
S 1452 EGPLPSSSPRSPSGLRPRGYT - 18669648
HTP
0.97
 - -
0.84
 - medium
T 1462 SPSGLRPRGYTISDSAPSRRG PKB_group 12150915
LTP
1.00
 MOD_PKB_1
 - -
0.76
 - medium
Y 1571 ILSNEHGSYRYTEFLTGLGRL - 11290735
LTP
1.00
 - Rap_GAP
0.15
 - medium
S 1798 YEVGQRKRLISSVEDFTEFV  RSK_group 15342917
LTP
1.00
 - -
0.32
 - medium

Substrate: Tuberin (GTPase activating protein)
Seq-ID: Q61037 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activator activity neural tube closure,
protein import into nucleus,
regulation of insulin receptor signaling pathway,
positive regulation of GTPase activity,
phosphoinositide 3-kinase cascade,
insulin-like growth factor receptor signaling pathway,
heart development,
negative regulation of phosphoinositide 3-kinase cascade,
positive chemotaxis,
protein kinase B signaling cascade,
regulation of small GTPase mediated signal transduction,
regulation of endocytosis,
negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 939 EKDSFRARSTSLNERPKSLRI - 17141160
LTP
1.00
 - -
0.46
 - medium
S 981 AAEAFRCRSISVSEHVVRSRI - 17242355
HTP
1.00
 - -
0.19
 - medium
S 1365 AGGIPIERAISSEGARPAVDL - 17242355
HTP
0.18
 - -
0.58
 - medium
S 1421 LSPEAKVRSQSGILDGEAATW - 17242355
HTP
0.12
 - -
0.58
 - medium
T 1465 SPSGLRPRGYTISDSAPSRRG - 15723049
LTP
1.00
 - -
0.72
 - medium
T 1465 SPSGLRPRGYTISDSAPSRRG - 17141160
LTP
1.00
 - -
0.72
 - medium

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