Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 126 DCLRDAMVRDYVRQTWKLEGE ZAP70 7961936
LTP
0.96
 - -
0.16
 2OQ1 39.30%
Y 248 YLKLKADGLIYCLKEACPNSS - 15592455
HTP
0.27
 - -
0.16
 2OQ1 37.55%
Y 248 YLKLKADGLIYCLKEACPNSS - 15659558
HTP
0.27
 - -
0.16
 2OQ1 37.55%
Y 248 YLKLKADGLIYCLKEACPNSS - 17192257
HTP
0.27
 - -
0.16
 2OQ1 37.55%
S 289 HPQRRIDTLNSDGYTPEPARI - 15144186
HTP
0.23
 - -
0.64
 --
Y 292 RRIDTLNSDGYTPEPARITSP Lck 8756661
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 8756661
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP Lck 7961936
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 7961936
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15144186
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15592455
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 16094384
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15659558
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 17192257
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 474 ARNVLLVNRHYAKISDFGLSK Lck 9685404
LTP
1.00
 SHC_group SH2 TyrKc
0.07
 1U59 13.97%
Y 492 LSKALGADDSYYTARSAGKWP Lck 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP - 12522270
HTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP - 15592455
HTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP ZAP70 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP - 16094384
HTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP - 15659558
HTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP - 17192257
HTP
1.00
 Fyn SH2 TyrKc
0.14
 1U59 13.10%
Y 493 SKALGADDSYYTARSAGKWPL Lck 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 8756661
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 7961936
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 7642520
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL - 12522270
HTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL - 15144186
HTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL - 15592455
HTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL ZAP70 11270871
LTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL - 16094384
HTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL - 15659558
HTP
1.00
 Fyn SH2 TyrKc
0.13
 1U59 68.12%

Valid HTML 4.01 Transitional