Substrate: hSIRT1 (Enzyme: Deacetylase)
Seq-ID: Q96EB6 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
NAD binding,
identical protein binding,
NAD-dependent histone deacetylase activity,
p53 binding,
transcription corepressor activity,
zinc ion binding,
protein C-terminus binding		 cytoplasm,
nucleolus,
nuclear envelope,
rDNA heterochromatin,
chromatin silencing complex,
PML body		 cellular response to starvation,
positive regulation of chromatin silencing,
rRNA processing,
establishment of chromatin silencing,
white fat cell differentiation,
apoptosis,
cell aging,
histone deacetylation,
regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
positive regulation of anti-apoptosis,
triglyceride mobilization,
regulation of apoptosis,
muscle organ development,
interspecies interaction between organisms,
regulation of cell proliferation,
DNA replication,
peptidyl-lysine deacetylation,
chromatin silencing at rDNA,
regulation of protein import into nucleus, translocation,
maintenance of chromatin silencing,
negative regulation of transcription factor activity,
transcription,
DNA repair,
negative regulation of fat cell differentiation,
negative regulation of helicase activity
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 27 AAGADREAASSPAGEPLRKRP - 15302935
HTP
0.32
 - -
0.92
 - medium
S 47 PRRDGPGLERSPGEPGGAAPE - 15302935
HTP
0.19
 - -
0.97
 - medium
S 47 PRRDGPGLERSPGEPGGAAPE - 17081983
HTP
0.19
 - -
0.97
 - medium
S 47 PRRDGPGLERSPGEPGGAAPE - 16964243
HTP
0.19
 - -
0.97
 - medium
S 47 PRRDGPGLERSPGEPGGAAPE - 18669648
HTP
0.19
 - -
0.97
 - medium
S 569 AAKSNDDLDVSESKGCMEEKP - 18669648
HTP
0.15
 - -
0.67
 - medium
T 719 PERAGGAGFGTDGDDQEAINE - 18669648
HTP
0.00
 - -
0.78
 - medium

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