a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	P06239 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   CBL_HUMAN MINT-56730   KSYK_HUMAN MINT-59474   LCP2_HUMAN MINT-59476   ZAP70_HUMAN MINT-60779   MK01_HUMAN MINT-60782   CD3Z_HUMAN MINT-61276   G3BP1_HUMAN MINT-66002   CD4_HUMAN MINT-66003   P85A_HUMAN MINT-68489   DLG1_HUMAN MINT-3373863   HS90A_HUMAN MINT-3373920   GCR_HUMAN MINT-7135817   SH22A_HUMAN MINT-7212471   KHDR1_HUMAN MINT-7212499   WASP_HUMAN MINT-7218109   ADA15_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK1	8226850	LTP	0.25		-	-	0.40	-	-
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK3	8226850	LTP	0.25		-	-	0.40	-	-
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK1	8506364	LTP	0.25		-	-	0.40	-	-
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK3	8506364	LTP	0.25		-	-	0.40	-	-
S	59	VTYEGSNPPASPLQDNLVIAL	-	15199125	LTP	0.43		-	-	0.43	2IIM	55.74%
S	158	HGSFLIRESESTAGSFSLSVR	-	8262984	LTP	0.04		-	SH2	0.29	1LKK	80.33%
S	162	LIRESESTAGSFSLSVRDFDQ	-	17192257	HTP	0.80		-	SH2	0.35	1LKK	12.30%
Y	192	KIRNLDNGGFYISPRITFPGL	-	15659558	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%
Y	192	KIRNLDNGGFYISPRITFPGL	-	17192257	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%
Y	192	KIRNLDNGGFYISPRITFPGL	-	18083107	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%
S	194	RNLDNGGFYISPRITFPGLHE	-	8262984	LTP	0.89		-	SH2	0.21	1LKK	18.85%
S	213	HELVRHYTNASDGLCTRLSRP	-	17192257	HTP	0.43		-	SH2	0.31	1LKK	38.52%
Y	394	GLARLIEDNEYTAREGAKFPI	Lck	3265417	LTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	15592455	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	15659558	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	17192257	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
T	501	RSVLEDFFTATEGQYQPQP	-	17192257	HTP	1.00		-	-	0.39	3LCK	53.42%
Y	505	EDFFTATEGQYQPQP	-	3265417	LTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	15592455	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	Lck	8945479	LTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	17192257	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	18083107	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	P42683 [Gallus gallus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine phosphatase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding plasma membrane, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	393	GLARLIEDNEYTAREGAKFPI	-	1545804	LTP	0.82		-	TyrKc	0.17	-	medium
Y	504	EDFFTATEGQYQQQP	-	1545804	LTP	0.93		-	-	0.48	-	medium

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	ENSP00000328213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	59	VTYEGSNPPASPLQDNLVIAL	MAPK_group	11847223	LTP	0.66	MOD_ProDKin_1	-	-	0.43	2IIM	55.74%